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Concentration-Dependent Effect of the Steroid Drug Prednisolone on a Lung Surfactant Monolayer

The lung surfactant monolayer (LSM) is the main barrier for particles entering the lung, including steroid drugs used to treat lung diseases. The present study combines Langmuir experiments and coarse-grained (CG) molecular dynamics simulations to investigate the concentration-dependent effect of st...

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Published in:Langmuir 2022-04, Vol.38 (14), p.4188-4199
Main Authors: Islam, Mohammad Zohurul, Krajewska, Martyna, Hossain, Sheikh I, Prochaska, Krystyna, Anwar, Azraf, Deplazes, Evelyne, Saha, Suvash C
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cited_by cdi_FETCH-LOGICAL-a2294-44d6caf9a4616f8ad97c70605aa223442a1b002b44d285ebdafbf2d5894b51fe3
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container_end_page 4199
container_issue 14
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container_title Langmuir
container_volume 38
creator Islam, Mohammad Zohurul
Krajewska, Martyna
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description The lung surfactant monolayer (LSM) is the main barrier for particles entering the lung, including steroid drugs used to treat lung diseases. The present study combines Langmuir experiments and coarse-grained (CG) molecular dynamics simulations to investigate the concentration-dependent effect of steroid drug prednisolone on the structure and morphology of a model LSM. The surface pressure–area isotherms for the Langmuir monolayers reveal a concentration-dependent decrease in area per lipid (APL). Results from simulations at a fixed surface tension, representing inhalation and exhalation conditions, suggest that at high drug concentrations, prednisolone induces a collapse of the LSM, which is likely caused by the inability of the drug to diffuse into the bilayer. Overall, the monolayer is most susceptible to drug-induced collapse at surface tensions representing exhalation conditions. The presence of cholesterol also exacerbates the instability. The findings of this investigation might be helpful for better understanding the interaction between steroid drug prednisolone and lung surfactants in relation to off-target effects.
doi_str_mv 10.1021/acs.langmuir.1c02817
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Lung
Prednisolone - pharmacology
Pulmonary Surfactants - chemistry
Surface Tension
Surface-Active Agents
title Concentration-Dependent Effect of the Steroid Drug Prednisolone on a Lung Surfactant Monolayer
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