Examining lung microstructure using 19 F MR diffusion imaging in COPD patients

To examine the time-dependent diffusion of fluorinated ( F) gas in human lungs for determination of surface-to-volume ratio in comparison to results from hyperpolarized Xe and lung function testing in healthy volunteers and patients with chronic obstructive pulmonary disease. Diffusion of fluorinate...

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Published in:Magnetic resonance in medicine 2022-08, Vol.88 (2), p.860-870
Main Authors: Obert, Arnd Jonathan, Gutberlet, Marcel, Kern, Agilo Luitger, Kaireit, Till Frederik, Glandorf, Julian, Moher Alsady, Tawfik, Wacker, Frank, Hohlfeld, Jens Michael, Vogel-Claussen, Jens
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Language:English
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Summary:To examine the time-dependent diffusion of fluorinated ( F) gas in human lungs for determination of surface-to-volume ratio in comparison to results from hyperpolarized Xe and lung function testing in healthy volunteers and patients with chronic obstructive pulmonary disease. Diffusion of fluorinated gas in the short-time regime was measured using multiple gradient-echo sequences with a single pair of trapezoidal gradient pulses. Pulmonary surface-to-volume ratio was calculated using a first-order approximation of the time-dependent diffusion in a study with 20 healthy volunteers and 22 patients with chronic obstructive pulmonary disease. The repeatability after 7 days as well as the correlation with hyperpolarized Xe diffusion MRI and lung function testing was analyzed. Using F diffusion MRI, the median surface-to-volume ratio is significantly decreased in chronic obstructive pulmonary disease patients (S/V = 126 cm [87-144 cm ]) compared with healthy volunteers (S/V = 164 cm [160-84 cm ], p 
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.29237