The association of various obstetric and perinatal factors with retinopathy of prematurity

• Published in: International ophthalmology 2022-09, Vol.42 (9), p.2719-2728
• Main Authors: Ozgur Gursoy, Ozlem, Gurer, Hulusi Goktug, Yildiz Eren, Ceren, Erdogan Ozgur, Pinar, Gursoy, Huseyin
• Format: Article
• Language: English
• Subjects: Continuous positive airway pressure; Diabetes; Diabetes mellitus; Gestational age; Heparin; Hypertension; Infants; Mechanical ventilation; Medicine; Medicine & Public Health; Obstetrics; Ophthalmology; Original Paper; Retinopathy; Risk analysis; Risk factors; Sepsis; Steroids
• ISSN: 1573-2630; 0165-5701; 1573-2630
• DOI: 10.1007/s10792-022-02260-2

Purpose To analyze the effects of various obstetric and perinatal factors on the severity of retinopathy of prematurity (ROP). Methods Infants born at ≤ 32 weeks of gestation, with less than 1500 g gestational weight and having at least stage 1 ROP, were reviewed. Group1A included treatment-requiring ROP (TR-ROP), and group 2A included the remaining patients not requiring treatment. Group 1B included stage 3 ROP cases, and group 2B included the remaining stage 2 or 1 ROP cases. Group 1C included cases with zone III disease, and group 2C the remaining. The control group (group C) was composed of premature infants without ROP. The multiple comparisons were made among groups 1A, 2A, and C; 1B, 2B, and C; 1C, 2C, and C. Results A total of 311 infants were included. Group 1A included 34 cases, group 1B 60, group 1C 51, and group C 98. Antenatal steroid administration, gestational diabetes mellitus (GDM), gestational weight (GW), gestational age (GA), sepsis, continuous positive airway pressure (CPAP) time, and invasive mechanical ventilation (MV) time were associated with TR-ROP, stage 3 ROP, and zone I, and II disease ( p