Genome sequence of Corynebacterium amycolatum ICIS 99 isolated from human vagina reveals safety and beneficial properties

Corynebacterium amycolatum ICIS 99 was isolated from vaginal smears of healthy women and showed promising results in antimicrobial screenings. Here, we report the draft genome sequence of this strain and analyze its main features to assess its safety and useful properties. The genome is 2,532,503 bp...

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Bibliographic Details
Published in:Archives of microbiology 2022-04, Vol.204 (4), p.226-226, Article 226
Main Authors: Gladysheva, Irina V., Khlopko, Yuriy A., Cherkasov, Sergey V., Kataev, Vladimir Ya
Format: Article
Language:English
Subjects:
Acid resistance
Antiinfectives and antibacterials
Bacteriocins
Bacteriocins - genetics
Base Composition
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cell Biology
Corynebacterium
Corynebacterium - genetics
Ecology
Female
Genes
Genomes
Humans
Life Sciences
Metabolites
Microbial Ecology
Microbiology
Nucleotide sequence
Original Paper
Oxidation resistance
Oxidative stress
Probiotics
Safety
Secondary metabolites
Vagina
Virulence
Virulence factors
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Summary:Corynebacterium amycolatum ICIS 99 was isolated from vaginal smears of healthy women and showed promising results in antimicrobial screenings. Here, we report the draft genome sequence of this strain and analyze its main features to assess its safety and useful properties. The genome is 2,532,503 bp long and contains 2186 CDSs with an average G + C content of 59.0%. Analyses of the ICIS 99 genome revealed the absence of true virulence factors. The genome contains genes involved in the synthesis of secondary metabolites and bacteriocins of the class sactipeptide. In the genome of ICIS 99, we identified a large number of genes responsible for adaptation and survival in the vaginal environment, including acid and oxidative stress resistance genes. The genomic information of ICIS 99 provides a basis for understanding the safety and useful properties of ICIS 99 and for considering it as a potential probiotic strain. The whole genome shotgun project has been deposited at DDBJ/ENA/GenBank under the accession number JAIUSU000000000.
ISSN:0302-8933
1432-072X
DOI:10.1007/s00203-022-02852-7