Clinical impact of NEC-associated sepsis on outcomes in preterm infants

Objective To determine risk factors and outcomes of necrotizing enterocolitis (NEC)-associated sepsis in infants with NEC. Methods A retrospective review comparing demographic and clinical information in infants with and without NEC-associated sepsis (defined as positive blood culture at the time of...

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Bibliographic Details
Published in:Pediatric research 2022-12, Vol.92 (6), p.1705-1715
Main Authors: Garg, Parvesh Mohan, Paschal, Jaslyn L., Ansari, Md Abu Yusuf, Block, Danielle, Inagaki, Kengo, Weitkamp, Jörn-Hendrik
Format: Article
Language:English
Subjects:
Birth Weight
Clinical Research Article
Enterocolitis, Necrotizing - complications
Enterocolitis, Necrotizing - surgery
Gallbladder diseases
Gastrointestinal diseases
Gestational Age
Gram-positive bacteria
Humans
Ileus
Infant
Infant, Newborn
Infant, Premature
Kidneys
Medicine
Medicine & Public Health
Necrosis
Pediatric Surgery
Pediatrics
Retrospective Studies
Sepsis
Sepsis - complications
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Summary:Objective To determine risk factors and outcomes of necrotizing enterocolitis (NEC)-associated sepsis in infants with NEC. Methods A retrospective review comparing demographic and clinical information in infants with and without NEC-associated sepsis (defined as positive blood culture at the time of NEC onset). Results A total of 209 infants with medical ( n  = 98) and surgical NEC ( n  = 111) had a median gestational age of 27 weeks (IQR 25; 30.5) and a median birth weight of 910 g [IQR 655; 1138]. Fifty of 209 (23.9%) infants had NEC-associated sepsis. Infants with NEC-associated sepsis had lower median GA (26.4 vs. 27.4 weeks; p  = 0.01), lower birth weight (745 vs. 930 g; p  = 0.009), were more likely mechanically ventilated [ p  
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-022-02034-7