Sodium selenite and Se-enriched yeast supplementation in atherosclerotic patients: Effects on the expression of pyroptosis-related genes and oxidative stress status

Atherosclerosis as a chronic inflammatory disorder of the arterial wall is the main leading cause of the cardiovascular disease (CVD). Caspase-dependent pyroptosis plays a pivotal role in the pathogenesis of CVD. Selenium (Se) is an important component of the antioxidant defense and plays a crucial...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2022-06, Vol.32 (6), p.1528-1537
Main Authors: Roshanravan, Neda, Koche Ghazi, Mahdiyeh Khabbaz, Ghaffari, Samad, Naemi, Mohammad, Alamdari, Naimeh Mesri, Shabestari, Alireza Namazi, Mosharkesh, Erfan, Soleimanzadeh, Hamid, Sadeghi, Mohammadreza Taban, Alipour, Shahriar, Bastani, Sepideh, Tarighat-Esfanjani, Ali
Format: Article
Language:English
Subjects:
Atherosclerosis
Cardiovascular disease
Inflammation
Pyroptosis
Selenium
Yeast
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Summary:Atherosclerosis as a chronic inflammatory disorder of the arterial wall is the main leading cause of the cardiovascular disease (CVD). Caspase-dependent pyroptosis plays a pivotal role in the pathogenesis of CVD. Selenium (Se) is an important component of the antioxidant defense and plays a crucial role in cardiovascular health. This study aimed to investigate the effects of daily consumption of sodium selenite and Se-enriched yeast on the expression of pyroptosis-related genes, and biomarkers of oxidative stress in patients with atherosclerosis. In this randomized, double-blinded, placebo-controlled clinical trial, 60 patients with atherosclerosis were recruited. Participants received 200 μg/day of sodium selenite, Se-enriched yeast, or placebo for 8 following weeks. The pyroptosis-related genes’ mRNA expression in peripheral blood mononuclear cells (PBMCs) was assessed before and after the intervention. Also, the levels of superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), and glutathione peroxidases (GPX) were measured at baseline and following the intervention. Following sodium selenite and Se-enriched yeast supplementation, the relative expression levels of TLR4, ASC, NLRP3, and NF-κB1 were significantly downregulated (p 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2022.02.014