Psychometric properties of the Lithuanian version of the patient-weighted inventory on quality of life in epilepsy

• Published in: Epilepsy & behavior 2022-05, Vol.130, p.108648-108648, Article 108648
• Main Authors: Puteikis, Kristijonas, Mameniškienė, Rūta
• Format: Article
• Language: English
• Subjects: Adult; Adverse events profile; Anxiety; Cross-Sectional Studies; Depression; Drug-Related Side Effects and Adverse Reactions; Epilepsy - psychology; Female; Humans; Lithuania; Male; Psychometrics - methods; Quality of Life - psychology; Reproducibility of Results; Seizure frequency; Seizures - complications
• ISSN: 1525-5050; 1525-5069
• DOI: 10.1016/j.yebeh.2022.108648

•We present psychometric properties of the Lithuanian QOLIE-31-P scale.•The Lithuanian QOLIE-31-P has good internal consistency and construct validity.•QOLIE-31-P correlates with short depression, anxiety, and adverse drug events scales.•QOLIE-31-P was also related to selected clinical and demographic variables. We aimed (1) to confirm that the Lithuanian version of the patient-weighted 31-item Quality of Life in Epilepsy Inventory (QOLIE-31-P) is a valid and reliable tool to be used among patients with epilepsy (PWE) in Lithuania and (2) to determine how the quality of life (QoL) is associated with demographic and clinical variables, adverse effects of antiseizure medication as well symptoms of depression and anxiety in this population. We used a translated and adapted Lithuanian version of the patient-weighted 31-item Quality of Life in Epilepsy Inventory (QOLIE-31-P) and conducted a cross-sectional anonymous survey among 303 adult PWE at a tertiary epilepsy center at Vilnius University Hospital Santaros Klinikos. The questionnaire also included the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), the Generalized anxiety disorder scale-7 (GAD-7), and the Liverpool Adverse Events Profile scale (LAEP). Missing values were replaced after performing multiple imputation (MI). QOLIE-31-P had high internal consistency (Cronbach’s α = 0.933 for all items and α = 0.676 to 0.906 for individual subscales). Its factor structure (71.2% of variance explained) consisted of seven factors, some of which overlapped (“Emotional Well-Being” and “Overall QoL”) or were split (“Social Function”) in comparison to the pre-defined content of the subscales. Multitrait-scaling revealed that each item is better correlated with the subscale it is included in than other subscales, suggesting good convergent and discriminant validity. On average, PWE scored 69.9 ± 16.8 (n = 164, mean = 64.9 after MI) on the QOLIE-31-P. Results were higher among male PWE, those employed or studying and having a higher level of education. In a pooled multiple regression model (adjusted R¯2 = 0.700, p