Short-term delay in neural response with multifocal contact lens might start at the retinal level

Introduction Multifocal simultaneous imaging challenges the visual system to process the multiple overlaps of focused and defocused images. Retinal image processing may be an important step in neuroadaptation to multifocal optical images. Our aims are, firstly to evaluate the short-term effect of di...

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Bibliographic Details
Published in:Documenta ophthalmologica 2022-08, Vol.144 (1), p.37-51
Main Authors: Fernandes, Paulo, Ferreira, Cesarina, Domingues, Joana, Sousa, Ana Amorim de, Ribeiro, Miguel António Faria, Queirós, António, González-Meijome, José M.
Format: Article
Language:English
Subjects:
Ciências da Saúde
Ciências Médicas
Contact lenses
Electroretinograms
Experiments
Image processing
Medicine
Medicine & Public Health
Multifocal contact lenses
Multifocal electroretinogram
Ophthalmology
Original Research Article
Retina
Science & Technology
Visual system
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Summary:Introduction Multifocal simultaneous imaging challenges the visual system to process the multiple overlaps of focused and defocused images. Retinal image processing may be an important step in neuroadaptation to multifocal optical images. Our aims are, firstly to evaluate the short-term effect of different multifocal contact lenses (MF) on retinal activity in young healthy subjects (Experiment#1) and secondly, to evaluate any changes in retinal activity in presbyopic patients fitted with MF over a 15-day period (Experiment#2). Methods In Experiment-#1, 10 emmetropic healthy young subjects were included to evaluate the short-term effect of different MFs designs. In Experiment #2, 4 presbyopic subjects were included to wear MF for 15 days. Following the ISCEV Standards, multifocal electroretinograms (mfERGs) were recorded to evaluate different retinal regions under different conditions: with single vision contact lens (SVCL) and with center-distance and center-near MF. Results In Exp#1 the peak time of N1, P1 and N2 were found to be delayed with the MF (p
ISSN:0012-4486
1573-2622
DOI:10.1007/s10633-022-09870-2