Clinical significance of soluble interleukin-2 receptor measurement in patients with idiopathic retroperitoneal fibrosis

Background Idiopathic retroperitoneal fibrosis (iRPF) is a rare chronic fibro-inflammatory disorder of unknown etiology. Activated T-helper cells, which shed soluble interleukin-2 receptor (sIL-2R) into the circulation, may play a pathogenetic role. Hence, measuring sIL-2R may be of value in monitor...

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Published in:International urology and nephrology 2022-10, Vol.54 (10), p.2663-2671
Main Authors: Kharagjitsing, H. H. S., Hendriksz, T. R., Fouraux, M. A., van Gelder, T., van Bommel, E. F. H.
Format: Article
Language:English
Subjects:
Clinical significance
Creatinine
Cytokines
Etiology
Fibrosis
Helper cells
Inflammatory diseases
Interleukin 2
Medicine
Medicine & Public Health
Nephrology
Nephrology - Original Paper
Patients
Prednisone
Urology
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Summary:Background Idiopathic retroperitoneal fibrosis (iRPF) is a rare chronic fibro-inflammatory disorder of unknown etiology. Activated T-helper cells, which shed soluble interleukin-2 receptor (sIL-2R) into the circulation, may play a pathogenetic role. Hence, measuring sIL-2R may be of value in monitoring disease activity and treatment response in iRPF patients. Methods We performed a prospective inception cohort study of 82 patients with untreated (re)active iRPF stratified by elevated (> 623 U/mL) or normal sIL-2R level at baseline and compared disease characteristics among these groups. Baseline and changes in sIL-2R levels following treatment with tamoxifen (TMX) or prednisone (PDN) were analyzed and related to treatment response. Results Median sIL-2R level was 668 U/mL (IQR 502.8–827.5); 48 patients (59%) had elevated baseline sIL-2R levels. Patients with elevated sIL-2R presented with higher CRP ( P  = 0.049) and serum creatinine (sCr) levels ( P  
ISSN:1573-2584
0301-1623
1573-2584
DOI:10.1007/s11255-022-03196-3