Progress and perspective of organoid technology in cancer-related translational medicine

Organoids are in vitro simplified and miniature microcosms of internal organs, which have aroused great interest in tissue development, multiple disease models, clinical diagnosis, as well as high-throughput drug screening and personalized medicine and so on. The success of physiology-related organo...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2022-05, Vol.149, p.112869-112869, Article 112869
Main Authors: Lin, Yusheng, Jiang, Li, He, Qiaojun, Yuan, Meng, Cao, Ji
Format: Article
Language:English
Subjects:
3D-culture
Cancer research
Clinical diagnosis
Neoplasms - drug therapy
Neoplasms - genetics
Organoid
Organoids
Personalized medicine
Precision Medicine
Technology
Translational medicine
Translational Research, Biomedical
Translational Science, Biomedical
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Summary:Organoids are in vitro simplified and miniature microcosms of internal organs, which have aroused great interest in tissue development, multiple disease models, clinical diagnosis, as well as high-throughput drug screening and personalized medicine and so on. The success of physiology-related organoid culture has greatly advanced the translational medicine research in the field of cancer treatment, which was once troubled by the inconsistency between two-dimensional (2D) cell culture and in vivo studies. Especially in recent years, the success rate of establish an organoid has been greatly improved, and the types of organoids have been gradually enriched. Moreover, the utilizing of some the cutting-edge technologies, including gene editing technology such as CRISPR-Cas9, the scope of application of organoid is broadened. In this review, we discuss the latest progress and applications of organoids, and also outline the potential challenges of organoids for future improvement. [Display omitted]
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2022.112869