Selective and Sensitive Fluorometric Determination of Piroxicam Based on Nitrogen-doped Graphene Quantum Dots and Gold Nanoparticles Coated with Phenylalanine

In this study, a sensitive fluorimetric method is proposed for the determination of piroxicam using nitrogen graphene quantum dots (N-GQDs) and gold nanoparticles coated with phenylalanine. The fluorescence emission of N-GQDs at 440 nm decreases with the increase of gold nanoparticles coated with ph...

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Bibliographic Details
Published in:Journal of fluorescence 2022-07, Vol.32 (4), p.1337-1346
Main Authors: Moallemi Bahmani, Maryam, Haji Shabani, Ali Mohammad, Dadfarnia, Shayessteh, Afsharipour, Roya
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biomedicine
Biophysics
Biotechnology
Emission
Fluorescence
Gold
Graphene
Nanoparticles
Nitrogen
Original Article
Phenylalanine
Quantum dots
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Summary:In this study, a sensitive fluorimetric method is proposed for the determination of piroxicam using nitrogen graphene quantum dots (N-GQDs) and gold nanoparticles coated with phenylalanine. The fluorescence emission of N-GQDs at 440 nm decreases with the increase of gold nanoparticles coated with phenylalanine. However, the addition of piroxicam causes the release of gold nanoparticles from the surface of quantum dots followed by the retrieval of the fluorescence emission of N-GQDs. Under the optimum conditions, the calibration graph was linear in the concentration range of 2.0–35.0 nmol L −1 for piroxicam with a limit of detection of 0.11 nmol L −1 . The developed method was successfully applied for the determination of piroxicam in urine and serum samples.
ISSN:1053-0509
1573-4994
DOI:10.1007/s10895-022-02907-4