Aqueous extract of Stevia rebaudiana (Bertoni) Bertoni abrogates death‐related signaling pathways via boosting the expression profile of oxidative defense systems

Indigenous inhabitants of South America and other areas have been using stevia as a traditional medicine for years, but its impact on cell signaling pathways has not been well studied yet. We evaluated the impacts of aqueous extract of Stevia rebaudiana (Bertoni) Bertoni on the expression of the sel...

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Bibliographic Details
Published in:Journal of food biochemistry 2022-07, Vol.46 (7), p.e14151-n/a
Main Authors: Oudbor, Leila, Mokhtari, Zohreh, Dastghaib, Sanaz, Mokarram, Pooneh, Rajani, Huda Fatima, Barazesh, Mahdi, Salami, Siamak
Format: Article
Language:English
Subjects:
antioxidant defense system
cell death modalities
CRI‐D2 cell line
diabetes mellitus type 1
Stevia rebaudiana
Wistar rat
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Summary:Indigenous inhabitants of South America and other areas have been using stevia as a traditional medicine for years, but its impact on cell signaling pathways has not been well studied yet. We evaluated the impacts of aqueous extract of Stevia rebaudiana (Bertoni) Bertoni on the expression of the selected genes involved in significant cell death modalities, including p53‐DNA damage and the cellular antioxidative defense in pancreatic tissues in STZ‐induced diabetic rats and murine pancreatic cell lines. The in vivo study revealed that aqueous extract of Stevia significantly upregulated the expression of GSTM1 and P1 and GPX (4.67, 12.08, and 2.81 fold, respectively; all p 
ISSN:0145-8884
1745-4514
DOI:10.1111/jfbc.14151