Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives

Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly intercon...

Full description

Saved in:
Bibliographic Details
Published in:Stroke (1970) 2022-05, Vol.53 (5), p.1487-1499
Main Authors: De Meyer, Simon F., Langhauser, Friederike, Haupeltshofer, Steffen, Kleinschnitz, Christoph, Casas, Ana I.
Format: Article
Language:English
Subjects:
Brain Ischemia - drug therapy
Humans
Inflammation
Stroke - drug therapy
Thromboinflammation
Thrombosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal damage following the ischemic event. Hence, we here review the most recent updates on thromboinflammatory-dependent mediators relevant after stroke focusing on recent discoveries on platelet modulation, a potential regulation of the innate and adaptive immune system in thromboinflammation, utterly providing a thorough up-to-date overview of all therapeutic approaches currently undergoing clinical trial.
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.122.038733