Periconceptional maternal social, lifestyle and medical risk factors impair embryonic growth: The Rotterdam Periconceptional Cohort

What is the association between the degree of a state of maternal vulnerability, determined by suboptimal periconceptional social, lifestyle and medical exposures and embryonic growth? In total, 555 pregnancies, comprising 324 naturally conceived pregnancies and 231 pregnancies conceived after IVF a...

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Bibliographic Details
Published in:Reproductive biomedicine online 2022-06, Vol.44 (6), p.1123-1133
Main Authors: van Zundert, Sofie K.M., van Rossem, Lenie, Willemsen, Sten P., van der Meer, Lindsey, Ernst-Smelt, Hiske E., Steegers-Theunissen, Régine P.M.
Format: Article
Language:English
Subjects:
Biomarkers
Crown–rump length
Embryonic Development
Embryonic volume
Female
Fertilization in Vitro - adverse effects
Humans
Life Style
Maternal vulnerability
Periconceptional period
Pregnancy
Prospective Studies
Risk Factors
Ultrasonography, Prenatal - methods
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Summary:What is the association between the degree of a state of maternal vulnerability, determined by suboptimal periconceptional social, lifestyle and medical exposures and embryonic growth? In total, 555 pregnancies, comprising 324 naturally conceived pregnancies and 231 pregnancies conceived after IVF and intracytoplasmic sperm injection (ICSI) were included from the Rotterdam Periconceptional Cohort (Predict Study) between November 2010 and August 2018. Data on periconceptional social, lifestyle and medical exposures, i.e. vulnerability markers, were collected through self-administered questionnaires. To estimate embryonic growth, crown–rump length (CRL) and embryonic volume measurements were taken at 7, 9 and 11 weeks of gestation using three-dimensional ultrasound scans and virtual reality techniques. Exposure to two or more vulnerability markers was negatively associated with embryonic growth in naturally conceived pregnancies. The CRL and embryonic volume trajectories of embryos of women exposed to two vulnerability markers were reduced compared with those of women exposed to zero or one vulnerability marker (√CRL: β = –0.29 mm, 95% CI –0.56 to –0.02; 3√EV: β = –0.14 cm3, 95% CI –0.27 to –0.01). These associations were not found in pregnancies conceived after IVF or ICSI. This study showed that a higher degree of the periconceptional state of maternal vulnerability is associated with reduced embryonic growth (CRL and embryonic volume) in naturally conceived pregnancies.
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2022.02.011