Recent trends of natural based therapeutics for mitochondria targeting in Alzheimer’s disease

•Alzheimer’s disease (AD) is the most ubiquitous neurodegenerative disorder.•Targeting multi-pathway via natural products may prevent mitochondria dysfunctionality.•We have focused on the pathophysiology events of mitochondrial dysfunction in AD. Alzheimer’s disease (AD) is the most ubiquitous neuro...

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Bibliographic Details
Published in:Mitochondrion 2022-05, Vol.64, p.112-124
Main Authors: Dhiman, Ashish, Handa, Mayank, Ruwali, Munindra, Singh, Dhirendra Pratap, Kesharwani, Prashant, Shukla, Rahul
Format: Article
Language:English
Subjects:
Aging
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Alzheimer’s disease
Apoptosis
Clinical
Humans
Mitochondria
Mitochondria - metabolism
Mitochondrial Dynamics
Oxidative Stress - physiology
Phytochemicals
Reactive oxygen species (ROS)
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Summary:•Alzheimer’s disease (AD) is the most ubiquitous neurodegenerative disorder.•Targeting multi-pathway via natural products may prevent mitochondria dysfunctionality.•We have focused on the pathophysiology events of mitochondrial dysfunction in AD. Alzheimer’s disease (AD) is the most ubiquitous neurodegenerative disorder with impaired cognitive functionality. Till date, the specific pathophysiology related to AD is still elusive. Recent reports suggest mitochondrial dysfunctionality like oxidative stress, Ca2+ disbalance, apoptosis, decrease energy and its metabolism plays an important. Recent reports about mitochondrial mechanisms and dynamics in AD unravelled new insights of molecular targets. Targeting multi-pathway via natural products may attenuate and prevent the mitochondria dysfunctionality. In this review, we have focused on the pathophysiology events of mitochondrial dysfunction in AD as well as mitochondrial fusion and fission mechanisms, role of aging in multicellular organisms, and how these connect to cell cycle regulation, and transmission of energy status.
ISSN:1567-7249
1872-8278
DOI:10.1016/j.mito.2022.03.006