Impact of COMT, PRODH and DISC1 Genetic Variants on Cognitive Performance of Patients with Schizophrenia

Cognitive impairment in schizophrenia (SCZ) is a core feature, relevant for the disease prognosis and functional capacity of the patients. It has also been identified as an endophenotype and proposed as a genetic mechanism of risk for schizophrenia. We aimed to evaluate the association of genetic va...

Full description

Saved in:
Bibliographic Details
Published in:Archives of medical research 2022-06, Vol.53 (4), p.388-398
Main Authors: Fricke-Galindo, Ingrid, Pérez-Aldana, Blanca E., Macías-Kauffer, Luis R., González-Arredondo, Susana, Dávila-Ortiz de Montellano, David, Aviña-Cervantes, Carlos L., López-López, Marisol, Rodríguez-Agudelo, Yaneth, Monroy-Jaramillo, Nancy
Format: Article
Language:English
Subjects:
Catechol O-Methyltransferase - genetics
Catechol-O-methyltransferase
Cognition
Disrupted in schizophrenia 1 protein
Genetic variants
Genotype
Humans
Nerve Tissue Proteins - genetics
Proline dehydrogenase
Proline Oxidase - genetics
Schizophrenia - complications
Schizophrenia - genetics
Schizophrenia spectrum disorders
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cognitive impairment in schizophrenia (SCZ) is a core feature, relevant for the disease prognosis and functional capacity of the patients. It has also been identified as an endophenotype and proposed as a genetic mechanism of risk for schizophrenia. We aimed to evaluate the association of genetic variants in COMT, PRODH, and DISC1 with the cognitive performance of Mexican-Mestizo adult patients with SCZ in order to identify endophenotypes. The association of seven variants in COMT, 15 in PRODH, and three in DISC1 was evaluated in 150 patients and 150 control volunteers. The MATRICS Consensus Cognitive Battery was administered to a subset of 44 patients and 42 controls. COMT rs4633 was related to MATRICS global assessment, while in the multi-phenotype analysis, PRODH rs2870984 was associated with processing speed, working memory, verbal learning, and social cognition. In addition, the association of variants in COMT and PRODH with the risk for SCZ was also found in Mexican-Mestizo patients. COMT might be a potential biomarker of cognitive impairment in Mexican-Mestizo patients with SCZ, supporting the relevance of this gene for drug design.
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2022.03.004