The Cardiac Sarcomere and Cell Cycle

Purpose of Review The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor lim...

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Bibliographic Details
Published in:Current cardiology reports 2022-06, Vol.24 (6), p.623-630
Main Authors: Pettinato, Anthony M., Ladha, Feria A., Hinson, J. Travis
Format: Article
Language:English
Subjects:
Cardiology
Cell Cycle
Cell Proliferation
Heart - physiology
Humans
Medicine
Medicine & Public Health
Myocytes, Cardiac
Regeneration
Regenerative Medicine (SM Wu
Sarcomeres - metabolism
Section Editor
Signal Transduction
Topical Collection on Regenerative Medicine
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Summary:Purpose of Review The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely understood mechanisms. Recent Findings This review summarizes known and emerging regulatory mechanisms connecting the human cardiomyocyte sarcomere to cell cycle regulation including structural and signaling mechanisms. Summary Cardiac regeneration could be augmented through targeting the inhibitory effects of the sarcomere on cardiomyocyte proliferation.
ISSN:1523-3782
1534-3170
1534-3170
DOI:10.1007/s11886-022-01682-9