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The Cardiac Sarcomere and Cell Cycle
Purpose of Review The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor lim...
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| Published in: | Current cardiology reports 2022-06, Vol.24 (6), p.623-630 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c347t-28ba0c42d9f3c10b6a0e92717af04eed6a85536160b5483e1a8d14bc99dee70e3 |
| container_end_page | 630 |
| container_issue | 6 |
| container_start_page | 623 |
| container_title | Current cardiology reports |
| container_volume | 24 |
| creator | Pettinato, Anthony M. Ladha, Feria A. Hinson, J. Travis |
| description | Purpose of Review
The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely understood mechanisms.
Recent Findings
This review summarizes known and emerging regulatory mechanisms connecting the human cardiomyocyte sarcomere to cell cycle regulation including structural and signaling mechanisms.
Summary
Cardiac regeneration could be augmented through targeting the inhibitory effects of the sarcomere on cardiomyocyte proliferation. |
| doi_str_mv | 10.1007/s11886-022-01682-9 |
| format | article |
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The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely understood mechanisms.
Recent Findings
This review summarizes known and emerging regulatory mechanisms connecting the human cardiomyocyte sarcomere to cell cycle regulation including structural and signaling mechanisms.
Summary
Cardiac regeneration could be augmented through targeting the inhibitory effects of the sarcomere on cardiomyocyte proliferation.</description><identifier>ISSN: 1523-3782</identifier><identifier>ISSN: 1534-3170</identifier><identifier>EISSN: 1534-3170</identifier><identifier>DOI: 10.1007/s11886-022-01682-9</identifier><identifier>PMID: 35380383</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cardiology ; Cell Cycle ; Cell Proliferation ; Heart - physiology ; Humans ; Medicine ; Medicine & Public Health ; Myocytes, Cardiac ; Regeneration ; Regenerative Medicine (SM Wu ; Sarcomeres - metabolism ; Section Editor ; Signal Transduction ; Topical Collection on Regenerative Medicine</subject><ispartof>Current cardiology reports, 2022-06, Vol.24 (6), p.623-630</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-28ba0c42d9f3c10b6a0e92717af04eed6a85536160b5483e1a8d14bc99dee70e3</citedby><cites>FETCH-LOGICAL-c347t-28ba0c42d9f3c10b6a0e92717af04eed6a85536160b5483e1a8d14bc99dee70e3</cites><orcidid>0000-0003-1455-113X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35380383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pettinato, Anthony M.</creatorcontrib><creatorcontrib>Ladha, Feria A.</creatorcontrib><creatorcontrib>Hinson, J. Travis</creatorcontrib><title>The Cardiac Sarcomere and Cell Cycle</title><title>Current cardiology reports</title><addtitle>Curr Cardiol Rep</addtitle><addtitle>Curr Cardiol Rep</addtitle><description>Purpose of Review
The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely understood mechanisms.
Recent Findings
This review summarizes known and emerging regulatory mechanisms connecting the human cardiomyocyte sarcomere to cell cycle regulation including structural and signaling mechanisms.
Summary
Cardiac regeneration could be augmented through targeting the inhibitory effects of the sarcomere on cardiomyocyte proliferation.</description><subject>Cardiology</subject><subject>Cell Cycle</subject><subject>Cell Proliferation</subject><subject>Heart - physiology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myocytes, Cardiac</subject><subject>Regeneration</subject><subject>Regenerative Medicine (SM Wu</subject><subject>Sarcomeres - metabolism</subject><subject>Section Editor</subject><subject>Signal Transduction</subject><subject>Topical Collection on Regenerative Medicine</subject><issn>1523-3782</issn><issn>1534-3170</issn><issn>1534-3170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPAzEQhC0EIiHwByjQFRQ0hvXjbF-JTrykSBSE2vL59iDRPYKdFPn3OFygpNqVdma08xFyyeCWAei7yJgxigLnFJgynBZHZMpyIalgGo73OxdUaMMn5CzGFQBPNnlKJiIXBoQRU3K9-MSsdKFeOp-9ueCHDgNmrq-zEts2K3e-xXNy0rg24sVhzsj748OifKbz16eX8n5OvZB6Q7mpHHjJ66IRnkGlHGDBNdOuAYlYK2fyXCimoMqlEcicqZmsfFHUiBpQzMjNmLsOw9cW48Z2y-jTG67HYRstV1LzVFqrJOWj1IchxoCNXYdl58LOMrB7OnakYxMd-0PHFsl0dcjfVh3Wf5ZfHEkgRkFMp_4Dg10N29Cnzv_FfgNLqW0x</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Pettinato, Anthony M.</creator><creator>Ladha, Feria A.</creator><creator>Hinson, J. Travis</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1455-113X</orcidid></search><sort><creationdate>20220601</creationdate><title>The Cardiac Sarcomere and Cell Cycle</title><author>Pettinato, Anthony M. ; Ladha, Feria A. ; Hinson, J. Travis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-28ba0c42d9f3c10b6a0e92717af04eed6a85536160b5483e1a8d14bc99dee70e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cardiology</topic><topic>Cell Cycle</topic><topic>Cell Proliferation</topic><topic>Heart - physiology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myocytes, Cardiac</topic><topic>Regeneration</topic><topic>Regenerative Medicine (SM Wu</topic><topic>Sarcomeres - metabolism</topic><topic>Section Editor</topic><topic>Signal Transduction</topic><topic>Topical Collection on Regenerative Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pettinato, Anthony M.</creatorcontrib><creatorcontrib>Ladha, Feria A.</creatorcontrib><creatorcontrib>Hinson, J. Travis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current cardiology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pettinato, Anthony M.</au><au>Ladha, Feria A.</au><au>Hinson, J. Travis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Cardiac Sarcomere and Cell Cycle</atitle><jtitle>Current cardiology reports</jtitle><stitle>Curr Cardiol Rep</stitle><addtitle>Curr Cardiol Rep</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>24</volume><issue>6</issue><spage>623</spage><epage>630</epage><pages>623-630</pages><issn>1523-3782</issn><issn>1534-3170</issn><eissn>1534-3170</eissn><abstract>Purpose of Review
The lack of adult human cardiomyocyte proliferative capacity impairs cardiac regeneration such as after myocardial injury. The sarcomere, a specialized actin cytoskeletal structure that is essential for twitch contraction in cardiomyocytes, has been considered a critical factor limiting adult human cardiomyocyte proliferation through incompletely understood mechanisms.
Recent Findings
This review summarizes known and emerging regulatory mechanisms connecting the human cardiomyocyte sarcomere to cell cycle regulation including structural and signaling mechanisms.
Summary
Cardiac regeneration could be augmented through targeting the inhibitory effects of the sarcomere on cardiomyocyte proliferation.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35380383</pmid><doi>10.1007/s11886-022-01682-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1455-113X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1523-3782 |
| ispartof | Current cardiology reports, 2022-06, Vol.24 (6), p.623-630 |
| issn | 1523-3782 1534-3170 1534-3170 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2647211876 |
| source | Springer Link |
| subjects | Cardiology Cell Cycle Cell Proliferation Heart - physiology Humans Medicine Medicine & Public Health Myocytes, Cardiac Regeneration Regenerative Medicine (SM Wu Sarcomeres - metabolism Section Editor Signal Transduction Topical Collection on Regenerative Medicine |
| title | The Cardiac Sarcomere and Cell Cycle |
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