Long‐term oncologic outcomes in esthesioneuroblastoma: An institutional experience of 143 patients

Objective Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory epithelium of the cribriform plate. The goal of this study was to update our oncologic outcomes for this disease and explore prognostic factors associated with survival. Materials and methods We performed a...

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Published in:International forum of allergy & rhinology 2022-12, Vol.12 (12), p.1457-1467
Main Authors: McMillan, Ryan A., Van Gompel, Jamie J., Link, Michael J., Moore, Eric J., Price, Daniel L., Stokken, Janalee K., Van Abel, Kathryn M., O'Byrne, Jamie, Giannini, Caterina, Chintakuntlawar, Ashish, Pinheiro Neto, Carlos D., Peris Celda, Maria, Foote, Robert, Choby, Garret
Format: Article
Language:English
Subjects:
anterior skull base
esthesioneuroblastoma
Head & neck cancer
Medical prognosis
Metastases
Metastasis
Multivariate analysis
Neuroblastoma
Olfactory epithelium
olfactory neuroblastoma
outcomes
sinonasal malignancy
Survival
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Summary:Objective Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory epithelium of the cribriform plate. The goal of this study was to update our oncologic outcomes for this disease and explore prognostic factors associated with survival. Materials and methods We performed a retrospective analysis of patients with ENB treated at a single tertiary care institution from January 1, 1960, to January 1, 2020. Univariate and multivariate analysis was performed. Overall survival (OS), progression‐free survival (PFS), and distant metastasis–free survival (DMFS) were reported. Results Among 143 included patients, the 5‐year OS was 82.3% and the 5‐year PFS was 51.6%; 5‐year OS and PFS have improved in the modern era (2005–present). Delayed regional nodal metastasis was the most common site of recurrence in 22% of patients (median, 57 months). On univariate analysis, modified Kadish staging (mKadish) had a negative effect on OS, PFS, and DMFS (p 
ISSN:2042-6976
2042-6984
DOI:10.1002/alr.23007