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Long‐term oncologic outcomes in esthesioneuroblastoma: An institutional experience of 143 patients
Objective Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory epithelium of the cribriform plate. The goal of this study was to update our oncologic outcomes for this disease and explore prognostic factors associated with survival. Materials and methods We performed a...
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| Published in: | International forum of allergy & rhinology 2022-12, Vol.12 (12), p.1457-1467 |
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| creator | McMillan, Ryan A. Van Gompel, Jamie J. Link, Michael J. Moore, Eric J. Price, Daniel L. Stokken, Janalee K. Van Abel, Kathryn M. O'Byrne, Jamie Giannini, Caterina Chintakuntlawar, Ashish Pinheiro Neto, Carlos D. Peris Celda, Maria Foote, Robert Choby, Garret |
| description | Objective
Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory epithelium of the cribriform plate. The goal of this study was to update our oncologic outcomes for this disease and explore prognostic factors associated with survival.
Materials and methods
We performed a retrospective analysis of patients with ENB treated at a single tertiary care institution from January 1, 1960, to January 1, 2020. Univariate and multivariate analysis was performed. Overall survival (OS), progression‐free survival (PFS), and distant metastasis–free survival (DMFS) were reported.
Results
Among 143 included patients, the 5‐year OS was 82.3% and the 5‐year PFS was 51.6%; 5‐year OS and PFS have improved in the modern era (2005–present). Delayed regional nodal metastasis was the most common site of recurrence in 22% of patients (median, 57 months). On univariate analysis, modified Kadish staging (mKadish) had a negative effect on OS, PFS, and DMFS (p |
| doi_str_mv | 10.1002/alr.23007 |
| format | article |
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Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory epithelium of the cribriform plate. The goal of this study was to update our oncologic outcomes for this disease and explore prognostic factors associated with survival.
Materials and methods
We performed a retrospective analysis of patients with ENB treated at a single tertiary care institution from January 1, 1960, to January 1, 2020. Univariate and multivariate analysis was performed. Overall survival (OS), progression‐free survival (PFS), and distant metastasis–free survival (DMFS) were reported.
Results
Among 143 included patients, the 5‐year OS was 82.3% and the 5‐year PFS was 51.6%; 5‐year OS and PFS have improved in the modern era (2005–present). Delayed regional nodal metastasis was the most common site of recurrence in 22% of patients (median, 57 months). On univariate analysis, modified Kadish staging (mKadish) had a negative effect on OS, PFS, and DMFS (p < 0.05). Higher Hyams grade had a negative effect on PFS and DMFS (p < 0.05). Positive margin status had a negative effect on PFS (p < 0.05). Orbital invasion demonstrated worsening OS (hazard ratio, 3.1; p < 0.05). On multivariable analysis, high Hyams grade (3 or 4), high mKadish stage (C+D), and increasing age were independent negative prognostic factors for OS (p < 0.05). High Hyams grade (3+4), high mKadish stage (C+D), age, and positive margin status were independent negative prognostic factors for PFS (p < 0.05). High Hyams grade (3+4) was an independent negative prognostic factor for DMFS (p < 0.05).
Conclusions
Patients with low Hyams grade and mKadish stage have favorable 5‐year OS, PFS, and DMFS.]]></description><identifier>ISSN: 2042-6976</identifier><identifier>EISSN: 2042-6984</identifier><identifier>DOI: 10.1002/alr.23007</identifier><identifier>PMID: 35385606</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>anterior skull base ; esthesioneuroblastoma ; Head & neck cancer ; Medical prognosis ; Metastases ; Metastasis ; Multivariate analysis ; Neuroblastoma ; Olfactory epithelium ; olfactory neuroblastoma ; outcomes ; sinonasal malignancy ; Survival</subject><ispartof>International forum of allergy & rhinology, 2022-12, Vol.12 (12), p.1457-1467</ispartof><rights>2022 ARS‐AAOA, LLC.</rights><rights>2022 ARS-AAOA, LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3937-978a22b04a585dbe3699b26daa9933a7e2675ab2158b1b947cd4696e2df62a913</citedby><cites>FETCH-LOGICAL-c3937-978a22b04a585dbe3699b26daa9933a7e2675ab2158b1b947cd4696e2df62a913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35385606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McMillan, Ryan A.</creatorcontrib><creatorcontrib>Van Gompel, Jamie J.</creatorcontrib><creatorcontrib>Link, Michael J.</creatorcontrib><creatorcontrib>Moore, Eric J.</creatorcontrib><creatorcontrib>Price, Daniel L.</creatorcontrib><creatorcontrib>Stokken, Janalee K.</creatorcontrib><creatorcontrib>Van Abel, Kathryn M.</creatorcontrib><creatorcontrib>O'Byrne, Jamie</creatorcontrib><creatorcontrib>Giannini, Caterina</creatorcontrib><creatorcontrib>Chintakuntlawar, Ashish</creatorcontrib><creatorcontrib>Pinheiro Neto, Carlos D.</creatorcontrib><creatorcontrib>Peris Celda, Maria</creatorcontrib><creatorcontrib>Foote, Robert</creatorcontrib><creatorcontrib>Choby, Garret</creatorcontrib><title>Long‐term oncologic outcomes in esthesioneuroblastoma: An institutional experience of 143 patients</title><title>International forum of allergy & rhinology</title><addtitle>Int Forum Allergy Rhinol</addtitle><description><![CDATA[Objective
Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory epithelium of the cribriform plate. The goal of this study was to update our oncologic outcomes for this disease and explore prognostic factors associated with survival.
Materials and methods
We performed a retrospective analysis of patients with ENB treated at a single tertiary care institution from January 1, 1960, to January 1, 2020. Univariate and multivariate analysis was performed. Overall survival (OS), progression‐free survival (PFS), and distant metastasis–free survival (DMFS) were reported.
Results
Among 143 included patients, the 5‐year OS was 82.3% and the 5‐year PFS was 51.6%; 5‐year OS and PFS have improved in the modern era (2005–present). Delayed regional nodal metastasis was the most common site of recurrence in 22% of patients (median, 57 months). On univariate analysis, modified Kadish staging (mKadish) had a negative effect on OS, PFS, and DMFS (p < 0.05). Higher Hyams grade had a negative effect on PFS and DMFS (p < 0.05). Positive margin status had a negative effect on PFS (p < 0.05). Orbital invasion demonstrated worsening OS (hazard ratio, 3.1; p < 0.05). On multivariable analysis, high Hyams grade (3 or 4), high mKadish stage (C+D), and increasing age were independent negative prognostic factors for OS (p < 0.05). High Hyams grade (3+4), high mKadish stage (C+D), age, and positive margin status were independent negative prognostic factors for PFS (p < 0.05). High Hyams grade (3+4) was an independent negative prognostic factor for DMFS (p < 0.05).
Conclusions
Patients with low Hyams grade and mKadish stage have favorable 5‐year OS, PFS, and DMFS.]]></description><subject>anterior skull base</subject><subject>esthesioneuroblastoma</subject><subject>Head & neck cancer</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Neuroblastoma</subject><subject>Olfactory epithelium</subject><subject>olfactory neuroblastoma</subject><subject>outcomes</subject><subject>sinonasal malignancy</subject><subject>Survival</subject><issn>2042-6976</issn><issn>2042-6984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp10MtKAzEUBuAgii3ahS8gATe6qM09E3eleIOCILoeMjOndWRmUpMM6s5H8Bl9EqOtLgSzScL5-El-hA4oOaWEsIlt_CnjhOgtNGREsLEymdj-PWs1QKMQHklakkpJ9S4acMkzqYgaomruuuXH23sE32LXla5xy7rEro-layHgusMQ4gOE2nXQe1c0NkTX2jM87dIwxDr2Mc1sg-FlBb6GrgTsFpgKjlc2pnsM-2hnYZsAo82-h-4vzu9mV-P5zeX1bDofl9xwPTY6s4wVRFiZyaoArowpmKqsNYZzq4EpLW3BqMwKWhihy0ooo4BVC8WsoXwPHa9zV9499endeVuHEprGduD6kDMlMqIEl1_06A99dL1P30hKC8q05plI6mStSu9C8LDIV75urX_NKcm_2s9T-_l3-8kebhL7ooXqV_50ncBkDZ7rBl7_T8qn89t15Cdv2o6-</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>McMillan, Ryan A.</creator><creator>Van Gompel, Jamie J.</creator><creator>Link, Michael J.</creator><creator>Moore, Eric J.</creator><creator>Price, Daniel L.</creator><creator>Stokken, Janalee K.</creator><creator>Van Abel, Kathryn M.</creator><creator>O'Byrne, Jamie</creator><creator>Giannini, Caterina</creator><creator>Chintakuntlawar, Ashish</creator><creator>Pinheiro Neto, Carlos D.</creator><creator>Peris Celda, Maria</creator><creator>Foote, Robert</creator><creator>Choby, Garret</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202212</creationdate><title>Long‐term oncologic outcomes in esthesioneuroblastoma: An institutional experience of 143 patients</title><author>McMillan, Ryan A. ; Van Gompel, Jamie J. ; Link, Michael J. ; Moore, Eric J. ; Price, Daniel L. ; Stokken, Janalee K. ; Van Abel, Kathryn M. ; O'Byrne, Jamie ; Giannini, Caterina ; Chintakuntlawar, Ashish ; Pinheiro Neto, Carlos D. ; Peris Celda, Maria ; Foote, Robert ; Choby, Garret</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3937-978a22b04a585dbe3699b26daa9933a7e2675ab2158b1b947cd4696e2df62a913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>anterior skull base</topic><topic>esthesioneuroblastoma</topic><topic>Head & neck cancer</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Multivariate analysis</topic><topic>Neuroblastoma</topic><topic>Olfactory epithelium</topic><topic>olfactory neuroblastoma</topic><topic>outcomes</topic><topic>sinonasal malignancy</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McMillan, Ryan A.</creatorcontrib><creatorcontrib>Van Gompel, Jamie J.</creatorcontrib><creatorcontrib>Link, Michael J.</creatorcontrib><creatorcontrib>Moore, Eric J.</creatorcontrib><creatorcontrib>Price, Daniel L.</creatorcontrib><creatorcontrib>Stokken, Janalee K.</creatorcontrib><creatorcontrib>Van Abel, Kathryn M.</creatorcontrib><creatorcontrib>O'Byrne, Jamie</creatorcontrib><creatorcontrib>Giannini, Caterina</creatorcontrib><creatorcontrib>Chintakuntlawar, Ashish</creatorcontrib><creatorcontrib>Pinheiro Neto, Carlos D.</creatorcontrib><creatorcontrib>Peris Celda, Maria</creatorcontrib><creatorcontrib>Foote, Robert</creatorcontrib><creatorcontrib>Choby, Garret</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International forum of allergy & rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McMillan, Ryan A.</au><au>Van Gompel, Jamie J.</au><au>Link, Michael J.</au><au>Moore, Eric J.</au><au>Price, Daniel L.</au><au>Stokken, Janalee K.</au><au>Van Abel, Kathryn M.</au><au>O'Byrne, Jamie</au><au>Giannini, Caterina</au><au>Chintakuntlawar, Ashish</au><au>Pinheiro Neto, Carlos D.</au><au>Peris Celda, Maria</au><au>Foote, Robert</au><au>Choby, Garret</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐term oncologic outcomes in esthesioneuroblastoma: An institutional experience of 143 patients</atitle><jtitle>International forum of allergy & rhinology</jtitle><addtitle>Int Forum Allergy Rhinol</addtitle><date>2022-12</date><risdate>2022</risdate><volume>12</volume><issue>12</issue><spage>1457</spage><epage>1467</epage><pages>1457-1467</pages><issn>2042-6976</issn><eissn>2042-6984</eissn><abstract><![CDATA[Objective
Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory epithelium of the cribriform plate. The goal of this study was to update our oncologic outcomes for this disease and explore prognostic factors associated with survival.
Materials and methods
We performed a retrospective analysis of patients with ENB treated at a single tertiary care institution from January 1, 1960, to January 1, 2020. Univariate and multivariate analysis was performed. Overall survival (OS), progression‐free survival (PFS), and distant metastasis–free survival (DMFS) were reported.
Results
Among 143 included patients, the 5‐year OS was 82.3% and the 5‐year PFS was 51.6%; 5‐year OS and PFS have improved in the modern era (2005–present). Delayed regional nodal metastasis was the most common site of recurrence in 22% of patients (median, 57 months). On univariate analysis, modified Kadish staging (mKadish) had a negative effect on OS, PFS, and DMFS (p < 0.05). Higher Hyams grade had a negative effect on PFS and DMFS (p < 0.05). Positive margin status had a negative effect on PFS (p < 0.05). Orbital invasion demonstrated worsening OS (hazard ratio, 3.1; p < 0.05). On multivariable analysis, high Hyams grade (3 or 4), high mKadish stage (C+D), and increasing age were independent negative prognostic factors for OS (p < 0.05). High Hyams grade (3+4), high mKadish stage (C+D), age, and positive margin status were independent negative prognostic factors for PFS (p < 0.05). High Hyams grade (3+4) was an independent negative prognostic factor for DMFS (p < 0.05).
Conclusions
Patients with low Hyams grade and mKadish stage have favorable 5‐year OS, PFS, and DMFS.]]></abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35385606</pmid><doi>10.1002/alr.23007</doi><tpages>11</tpages></addata></record> |
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| subjects | anterior skull base esthesioneuroblastoma Head & neck cancer Medical prognosis Metastases Metastasis Multivariate analysis Neuroblastoma Olfactory epithelium olfactory neuroblastoma outcomes sinonasal malignancy Survival |
| title | Long‐term oncologic outcomes in esthesioneuroblastoma: An institutional experience of 143 patients |
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