Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity

Eight pentacyclic triterpenoids including two new ones ( 1 , 2 ) were isolated from the fruits of Xanthium strumarium . Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for in vitro cytotoxic activity on HepG2, A549, HCT116 and SW480 cancer cells. Amo...

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Bibliographic Details
Published in:Journal of natural medicines 2022-03, Vol.76 (2), p.468-475
Main Authors: Xu, Xiang-Wei, Xi, Yi-Yuan, Chen, Jun, Zhang, Feng, Zheng, Ju-Jia, Zhang, Peng-Hai
Format: Article
Language:English
Subjects:
Annexin V
Antifungal agents
Antineoplastic Agents
Biomedical and Life Sciences
Biomedicine
Cell cycle
cell cycle checkpoints
Cell death
Complementary & Alternative Medicine
Cytotoxicity
death
Fruit
G1 phase
interphase
Medicinal Chemistry
Pentacyclic triterpenoids
Pharmacology/Toxicology
Pharmacy
phytochemicals
Phytochemicals - pharmacology
Plant Sciences
spectral analysis
Triterpenoids
Xanthium - chemistry
Xanthium strumarium
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Summary:Eight pentacyclic triterpenoids including two new ones ( 1 , 2 ) were isolated from the fruits of Xanthium strumarium . Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for in vitro cytotoxic activity on HepG2, A549, HCT116 and SW480 cancer cells. Among them, the new compound 2 was found to exhibit significant cytotoxic activity on A549, HCT116 and SW480 cancer cells with IC 50 values of 9.68, 4.27 and 7.58 μM, respectively. Further, 2 was selected for cell cycle analysis and results revealed that 2 could cause HCT116 cell cycle arrest in G1 phase. In addition, Annexin V-FITC/PI staining assay showed that 2 could induce the death of HCT116 cells. Graphical abstract
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-021-01588-w