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Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity
Eight pentacyclic triterpenoids including two new ones ( 1 , 2 ) were isolated from the fruits of Xanthium strumarium . Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for in vitro cytotoxic activity on HepG2, A549, HCT116 and SW480 cancer cells. Amo...
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| Published in: | Journal of natural medicines 2022-03, Vol.76 (2), p.468-475 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c432t-b3cbca7a396df84ce411857055b419fe7cb926fa1212b40c0af0b351a3576a533 |
| container_end_page | 475 |
| container_issue | 2 |
| container_start_page | 468 |
| container_title | Journal of natural medicines |
| container_volume | 76 |
| creator | Xu, Xiang-Wei Xi, Yi-Yuan Chen, Jun Zhang, Feng Zheng, Ju-Jia Zhang, Peng-Hai |
| description | Eight pentacyclic triterpenoids including two new ones (
1
,
2
) were isolated from the fruits of
Xanthium strumarium
. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for in vitro cytotoxic activity on HepG2, A549, HCT116 and SW480 cancer cells. Among them, the new compound
2
was found to exhibit significant cytotoxic activity on A549, HCT116 and SW480 cancer cells with IC
50
values of 9.68, 4.27 and 7.58 μM, respectively. Further,
2
was selected for cell cycle analysis and results revealed that
2
could cause HCT116 cell cycle arrest in G1 phase. In addition, Annexin V-FITC/PI staining assay showed that
2
could induce the death of HCT116 cells.
Graphical abstract |
| doi_str_mv | 10.1007/s11418-021-01588-w |
| format | article |
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1
,
2
) were isolated from the fruits of
Xanthium strumarium
. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for in vitro cytotoxic activity on HepG2, A549, HCT116 and SW480 cancer cells. Among them, the new compound
2
was found to exhibit significant cytotoxic activity on A549, HCT116 and SW480 cancer cells with IC
50
values of 9.68, 4.27 and 7.58 μM, respectively. Further,
2
was selected for cell cycle analysis and results revealed that
2
could cause HCT116 cell cycle arrest in G1 phase. In addition, Annexin V-FITC/PI staining assay showed that
2
could induce the death of HCT116 cells.
Graphical abstract</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-021-01588-w</identifier><identifier>PMID: 34993755</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Annexin V ; Antifungal agents ; Antineoplastic Agents ; Biomedical and Life Sciences ; Biomedicine ; Cell cycle ; cell cycle checkpoints ; Cell death ; Complementary & Alternative Medicine ; Cytotoxicity ; death ; Fruit ; G1 phase ; interphase ; Medicinal Chemistry ; Pentacyclic triterpenoids ; Pharmacology/Toxicology ; Pharmacy ; phytochemicals ; Phytochemicals - pharmacology ; Plant Sciences ; spectral analysis ; Triterpenoids ; Xanthium - chemistry ; Xanthium strumarium</subject><ispartof>Journal of natural medicines, 2022-03, Vol.76 (2), p.468-475</ispartof><rights>The Japanese Society of Pharmacognosy 2021</rights><rights>2021. The Japanese Society of Pharmacognosy.</rights><rights>The Japanese Society of Pharmacognosy 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-b3cbca7a396df84ce411857055b419fe7cb926fa1212b40c0af0b351a3576a533</citedby><cites>FETCH-LOGICAL-c432t-b3cbca7a396df84ce411857055b419fe7cb926fa1212b40c0af0b351a3576a533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34993755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Xiang-Wei</creatorcontrib><creatorcontrib>Xi, Yi-Yuan</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Zhang, Feng</creatorcontrib><creatorcontrib>Zheng, Ju-Jia</creatorcontrib><creatorcontrib>Zhang, Peng-Hai</creatorcontrib><title>Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Eight pentacyclic triterpenoids including two new ones (
1
,
2
) were isolated from the fruits of
Xanthium strumarium
. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for in vitro cytotoxic activity on HepG2, A549, HCT116 and SW480 cancer cells. Among them, the new compound
2
was found to exhibit significant cytotoxic activity on A549, HCT116 and SW480 cancer cells with IC
50
values of 9.68, 4.27 and 7.58 μM, respectively. Further,
2
was selected for cell cycle analysis and results revealed that
2
could cause HCT116 cell cycle arrest in G1 phase. In addition, Annexin V-FITC/PI staining assay showed that
2
could induce the death of HCT116 cells.
Graphical abstract</description><subject>Annexin V</subject><subject>Antifungal agents</subject><subject>Antineoplastic Agents</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell cycle</subject><subject>cell cycle checkpoints</subject><subject>Cell death</subject><subject>Complementary & Alternative Medicine</subject><subject>Cytotoxicity</subject><subject>death</subject><subject>Fruit</subject><subject>G1 phase</subject><subject>interphase</subject><subject>Medicinal Chemistry</subject><subject>Pentacyclic triterpenoids</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>phytochemicals</subject><subject>Phytochemicals - pharmacology</subject><subject>Plant Sciences</subject><subject>spectral analysis</subject><subject>Triterpenoids</subject><subject>Xanthium - chemistry</subject><subject>Xanthium strumarium</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqNkU1PHDEMhqOKqny0f6AHNFIvvQzEcZJJjhWigLQSHIrUSxVlshk2aGeGJhlg_z1ZdilSD4iTbfnxa9kvIV-BHgGlzXEC4KBqyqCmIJSqHz6QPVCylEzjTsmR0xo5x12yn9ItpZwhwieyi1xrbITYI3-uFqs8uoXvg7PLKgz3PuVwY3MYh2rsqrzwVRenkNO6-m2HvAhTX6Ucp97GdWqH-ZoKsXJFKY-PwVXW5XAf8uoz-djZZfJftvGAXP88_XVyXs8uzy5Ofsxqx5HlukXXOttY1HLeKe48B1CioUK0HHTnG9dqJjsLDFjLqaO2oy0KsCgaaQXiAfm-0b2L49-pXGD6kJxfLu3gxykZJrlSgkqEd6CgGMpGy4J--w-9Hac4lEMKhVSXL0pdKLahXBxTir4zdzGU36wMULP2yWx8MsUn8-yTeShDh1vpqe39_N_IizEFwA2QSmu48fF19xuyT-10nrU</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Xu, Xiang-Wei</creator><creator>Xi, Yi-Yuan</creator><creator>Chen, Jun</creator><creator>Zhang, Feng</creator><creator>Zheng, Ju-Jia</creator><creator>Zhang, Peng-Hai</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20220301</creationdate><title>Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity</title><author>Xu, Xiang-Wei ; Xi, Yi-Yuan ; Chen, Jun ; Zhang, Feng ; Zheng, Ju-Jia ; Zhang, Peng-Hai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-b3cbca7a396df84ce411857055b419fe7cb926fa1212b40c0af0b351a3576a533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Annexin V</topic><topic>Antifungal agents</topic><topic>Antineoplastic Agents</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell cycle</topic><topic>cell cycle checkpoints</topic><topic>Cell death</topic><topic>Complementary & Alternative Medicine</topic><topic>Cytotoxicity</topic><topic>death</topic><topic>Fruit</topic><topic>G1 phase</topic><topic>interphase</topic><topic>Medicinal Chemistry</topic><topic>Pentacyclic triterpenoids</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>phytochemicals</topic><topic>Phytochemicals - pharmacology</topic><topic>Plant Sciences</topic><topic>spectral analysis</topic><topic>Triterpenoids</topic><topic>Xanthium - chemistry</topic><topic>Xanthium strumarium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Xiang-Wei</creatorcontrib><creatorcontrib>Xi, Yi-Yuan</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Zhang, Feng</creatorcontrib><creatorcontrib>Zheng, Ju-Jia</creatorcontrib><creatorcontrib>Zhang, Peng-Hai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Xiang-Wei</au><au>Xi, Yi-Yuan</au><au>Chen, Jun</au><au>Zhang, Feng</au><au>Zheng, Ju-Jia</au><au>Zhang, Peng-Hai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>76</volume><issue>2</issue><spage>468</spage><epage>475</epage><pages>468-475</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Eight pentacyclic triterpenoids including two new ones (
1
,
2
) were isolated from the fruits of
Xanthium strumarium
. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for in vitro cytotoxic activity on HepG2, A549, HCT116 and SW480 cancer cells. Among them, the new compound
2
was found to exhibit significant cytotoxic activity on A549, HCT116 and SW480 cancer cells with IC
50
values of 9.68, 4.27 and 7.58 μM, respectively. Further,
2
was selected for cell cycle analysis and results revealed that
2
could cause HCT116 cell cycle arrest in G1 phase. In addition, Annexin V-FITC/PI staining assay showed that
2
could induce the death of HCT116 cells.
Graphical abstract</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34993755</pmid><doi>10.1007/s11418-021-01588-w</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of natural medicines, 2022-03, Vol.76 (2), p.468-475 |
| issn | 1340-3443 1861-0293 |
| language | eng |
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| source | Springer Link |
| subjects | Annexin V Antifungal agents Antineoplastic Agents Biomedical and Life Sciences Biomedicine Cell cycle cell cycle checkpoints Cell death Complementary & Alternative Medicine Cytotoxicity death Fruit G1 phase interphase Medicinal Chemistry Pentacyclic triterpenoids Pharmacology/Toxicology Pharmacy phytochemicals Phytochemicals - pharmacology Plant Sciences spectral analysis Triterpenoids Xanthium - chemistry Xanthium strumarium |
| title | Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity |
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