Successful organoid-mediated generation of iPSC-derived CAR-T cells

Artificial thymic organoids (ATOs) allow the selective differentiation of chimeric antigen receptor (CAR)-transduced human iPSCs into CAR-T cells. In this issue of Cell Stem Cell, Wang et al. now use ATOs to produce human CD19 CAR-T cells that mimic conventional CAR-T cells and effectively control t...

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Bibliographic Details
Published in:Cell stem cell 2022-04, Vol.29 (4), p.493-495
Main Author: Kaneko, Shin
Format: Article
Language:English
Subjects:
Animals
Humans
Immunotherapy, Adoptive
Induced Pluripotent Stem Cells
Organoids
Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen
T-Lymphocytes
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Summary:Artificial thymic organoids (ATOs) allow the selective differentiation of chimeric antigen receptor (CAR)-transduced human iPSCs into CAR-T cells. In this issue of Cell Stem Cell, Wang et al. now use ATOs to produce human CD19 CAR-T cells that mimic conventional CAR-T cells and effectively control the progression of human CD19 leukemia in an animal model.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2022.03.005