β‑Cyclodextrin-Based Ultrahigh Stretchable, Flexible, Electro- and Pressure-Responsive, Adhesive, Transparent Hydrogel as Motion Sensor

• Published in: ACS applied materials & interfaces 2022-04, Vol.14 (15), p.17065-17080
• Main Authors: Roy, Arpita, Manna, Kalipada, Ray, Preetam Guha, Dhara, Santanu, Pal, Sagar
• Format: Article
• Language: English
• Subjects: Acrylamide; Adhesives; beta-Cyclodextrins; Biological and Medical Applications of Materials and Interfaces; Humans; Hydrogels; Wearable Electronic Devices
• ISSN: 1944-8244; 1944-8252
• DOI: 10.1021/acsami.2c00101

In the present work, a multiple-stimuli-responsive hydrogel has been synthesized via polymerization of acrylamide (AAm) and N-hydroxy methyl acrylamide (HMAm) on β-cyclodextrin (β-CD). The synthesized hydrogel β-CD-g-(pAAm/pHMAm) exhibited various striking features like ultrahigh stretchability (>6000%), flexibility, stab resistivity, self-recoverability, electroresponsiveness, pressure-responsiveness, adhesiveness, and high transparency (>90%). Besides, the hydrogel has demonstrated enhanced biocompatibility, UV resistance, and thermoresponsive shape memory behaviors. On the basis of these attractive characteristics of the hydrogel, a flexible pressure sensor for the real-time monitoring of human motion with superior biocompatibility and transparency was fabricated. Moreover, due to the nanofibrillar surface morphology of the β-CD-g-(pAAm/pHMAm) hydrogel, the sensor based on the gel exhibited high sensitivity (0.053 kPa–1 for 0–3.3 kPa). The flexible sensor demonstrates very fast response time (130 ms-210 ms) with adequate stability (5000 cycles). Interestingly, the sensor can rapidly sense both robust (index finger and wrist) motions as well as tiny (swallowing and phonation) physiological actions. In addition, this adhesive hydrogel patch also acts as a potential carrier for the sustained topical release of (∼80.8% in 48 h) the antibiotic drug gentamicin sulfate.