The characteristics, tumorigenicities and therapeutics of cancer stem cells based on circRNAs

Currently, recurrence and metastasis are still the main causes leading to the failure of various therapies for malignant tumors. In view of this, research on cancer stem cells (CSCs) has received increasing attention. CSCs are a subgroup of cancer cells with the characteristics of self-renewal, mult...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2022-05, Vol.233, p.153822-153822, Article 153822
Main Authors: Zhou, Peng, Chen, Xingyu, Shi, Kaihang, Qu, Huiheng, Xia, Jiazeng
Format: Article
Language:English
Subjects:
Biomarker
Cancer stem cell
Cell Differentiation
CircRNA
Humans
Neoplasms - genetics
Neoplasms - therapy
Neoplastic Stem Cells
RNA, Circular - genetics
Targeted therapy
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Summary:Currently, recurrence and metastasis are still the main causes leading to the failure of various therapies for malignant tumors. In view of this, research on cancer stem cells (CSCs) has received increasing attention. CSCs are a subgroup of cancer cells with the characteristics of self-renewal, multidirectional differentiation, and immortal proliferation, and are closely related to resistance, metastasis, and recurrence. Circular RNAs (circRNAs) are a type of noncoding RNA (ncRNA) containing a covalent closed loop and are characterized by their abundance, stability, conservation, and tissue specificity. In this article, we focus on the characteristics of CSCs and review the latest research advances on the role of circRNAs in CSCs.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2022.153822