Targeting The Tumor Microenvironment in Lymphomas: Emerging Biological Insights and Therapeutic Strategies

Purpose of Review This review aims to discuss recent advances in elucidating the tumor microenvironment (TME) in B lymphomas and resultant novel therapeutic development. Recent Findings While tumor morphology, immunophenotype, and molecular profile are established factors that predict outcome and gu...

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Bibliographic Details
Published in:Current oncology reports 2022-09, Vol.24 (9), p.1121-1131
Main Authors: Cook, Michael R., Dunleavy, Kieron
Format: Article
Language:English
Subjects:
Cell interactions
Cell lineage
Extracellular matrix
Lymphocytes B
Lymphoma
Lymphomas (T Hilal
Medicine
Medicine & Public Health
Oncology
Section Editor
Topical Collection on Lymphomas
Tumor cells
Tumor microenvironment
Tumor-infiltrating lymphocytes
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Summary:Purpose of Review This review aims to discuss recent advances in elucidating the tumor microenvironment (TME) in B lymphomas and resultant novel therapeutic development. Recent Findings While tumor morphology, immunophenotype, and molecular profile are established factors that predict outcome and guide therapy, the prognostic impact of infiltrating, non-tumor cells is now emerging. This is simultaneously facilitating the development of new therapies that target non-tumor cells. Summary The tumor microenvironment (TME) is a complex ecosystem composed of infiltrating cells and byproducts, extracellular matrix, and other non-cellular tissues. In lymphomas, our current understanding of the role of the TME is principally informed by studies in B-cell lineage diseases. As we improve our understanding of lymphoma biology, the importance of the impact of the non-tumor cell microenvironment is becoming more apparent. This lays the foundation for the investigation and development of novel therapies and combination strategies that target non-tumor cells and tumor cell/non-tumor cell interactions.
ISSN:1523-3790
1534-6269
DOI:10.1007/s11912-022-01250-y