Nucleolin: a binding partner of G-quadruplex structures

Nucleolin protein is involved in a plethora of cellular pathways across the nucleolus, nucleus, and cytoplasm. The association of its RNA-binding domain (RBD) and its RGG (arginine–glycine–glycine-rich) domain allows it to interact with G-quadruplex structures in nucleic acids. We highlight evidence...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cell biology 2022-07, Vol.32 (7), p.561-564
Main Authors: Santos, Tiago, Salgado, Gilmar F., Cabrita, Eurico J., Cruz, Carla
Format: Article
Language:English
Subjects:
Binding
Cellular structure
Cytoplasm
Domains
G-quadruplex
G-Quadruplexes
Glycine
Humans
interaction
ligands
Neoplasms
Neurodegenerative Diseases
Nucleic acids
Nucleoli
Nucleolin
Phosphoproteins - metabolism
Protein Binding
RNA-Binding Proteins - metabolism
Virus Diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nucleolin protein is involved in a plethora of cellular pathways across the nucleolus, nucleus, and cytoplasm. The association of its RNA-binding domain (RBD) and its RGG (arginine–glycine–glycine-rich) domain allows it to interact with G-quadruplex structures in nucleic acids. We highlight evidence that the nucleolin/G-quadruplex partnership is of extensive relevance to neurodegenerative disease, cancer, and viral infections.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2022.03.003