Non-coding RNAs and macrophage interaction in tumor progression

The macrophages are abundantly found in TME and their M2 polarization is in favor of tumor malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage polarization in TME to affect cancer progression. The miRNAs can dually induce/suppress M2 polarization of macrophages and by aff...

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Published in:Critical reviews in oncology/hematology 2022-05, Vol.173, p.103680-103680, Article 103680
Main Authors: Entezari, Maliheh, Sadrkhanloo, Mehrdokht, Rashidi, Mohsen, Asnaf, Sholeh Etehad, Taheriazam, Afshin, Hashemi, Mehrdad, Ashrafizadeh, Milad, Zarrabi, Ali, Rabiee, Navid, Hushmandi, Kiavash, Mirzaei, Sepideh, Sethi, Gautam
Format: Article
Language:English
Subjects:
Cancer therapy
CircRNAs
Drug resistance
Exosomes
Exosomes - genetics
Exosomes - metabolism
Humans
Long non-coding RNAs
Macrophages - pathology
MicroRNAs - genetics
MicroRNAs - metabolism
MiRNAs
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - therapy
RNA, Circular
RNA, Long Noncoding - genetics
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Summary:The macrophages are abundantly found in TME and their M2 polarization is in favor of tumor malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage polarization in TME to affect cancer progression. The miRNAs can dually induce/suppress M2 polarization of macrophages and by affecting various molecular pathways, they modulate tumor progression and therapy response. The lncRNAs can affect miRNAs via sponging and other molecular pathways to modulate macrophage polarization. A few experiments have also examined role of circRNAs in targeting signaling networks and affecting macrophages. The therapeutic targeting of these ncRNAs can mediate TME remodeling and affect macrophage polarization. Furthermore, exosomal ncRNAs derived from tumor cells or macrophages can modulate polarization and TME remodeling. Suppressing biogenesis and secretion of exosomes can inhibit ncRNA-mediated M2 polarization of macrophages and prevent tumor progression. The ncRNAs, especially exosomal ncRNAs can be considered as non-invasive biomarkers for tumor diagnosis. •M2-polarized macrophages demonstrate immuno-suppressive activities.•Non-coding RNAs can regulate the process of tumorigenesis.•Macrophages can secrete exosomes containing non-coding RNAs.•LncRNAs and circRNAs can regulate miRNAs in affecting macrophage polarization.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2022.103680