Responsive hydrogel-based microneedle dressing for diabetic wound healing

Wound healing is a critical challenge in diabetic patients, mainly due to long-term dysglycemia and its related pathological complications. Subcutaneous insulin injection represents a typical clinical solution, while the low controllability of insulin administration commonly leads to a result far fr...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2022-05, Vol.1 (18), p.351-3511
Main Authors: Guo, Zhaoyang, Liu, Haiyang, Shi, Zhekun, Lin, Lulu, Li, Yinping, Wang, Miao, Pan, Guoqing, Lei, Yifeng, Xue, Longjian
Format: Article
Language:English
Subjects:
Biocompatibility
Blood glucose
Collagen
Complications
Diabetes
Diabetes mellitus
Fabrication
Gelatin
Glucose
Hydrogels
Inflammation
Insulin
Mechanical properties
Mold dressing
Needles
Skin
Skin injuries
Wound healing
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Summary:Wound healing is a critical challenge in diabetic patients, mainly due to long-term dysglycemia and its related pathological complications. Subcutaneous insulin injection represents a typical clinical solution, while the low controllability of insulin administration commonly leads to a result far from the optimal therapeutic effect. In this work, we developed a glucose-responsive insulin-releasing hydrogel for microneedle dressing fabrication and then investigated its effects on diabetic wound healing. The hydrogel system was composed of biocompatible gelatin methacrylate (GelMa), glucose-responsive monomer 4-(2-acrylamidoethylcarbamoyl)-3-fluorophenylboronic acid (AFPBA) and gluconic insulin (G-insulin), and the Gel-AFPBA-ins hydrogel-based microneedle dressing was developed by replicating PDMS molds. The resultant hydrogel microneedle dressing exhibited adequate mechanical properties, high biocompatibility, glucose-responsive insulin release behavior upon exposure to different glucose solutions, and potent adhesion to the skin compared to hydrogels without microstructures. The microneedle dressing could accelerate the diabetic wound healing process with decreased inflammatory reaction, enhanced collagen deposition on the regenerated tissue sites, and improved blood glucose control in animals. Therefore, the glucose-responsive insulin-releasing hydrogel microneedle dressing is effective in diabetic wound management and has potential for treatment of other chronic skin injuries. A glucose-responsive insulin-releasing hydrogel microneedle dressing was developed with the aim to accelerate wound healing in type 1 diabetic mice.
ISSN:2050-750X
2050-7518
DOI:10.1039/d2tb00126h