Microbes-myeloid-tumor: a colonic triad against T cells

Immune checkpoint blockade has dramatically improved cancer therapy but remains ineffective for most colorectal tumors. In this issue of Immunity, Peuker et al. describe a microbiota-myeloid-tumor cell crosstalk that inhibits CD8 T cells and promotes colorectal cancer progression.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2022-04, Vol.55 (4), p.582-585
Main Authors: Lopès, Amélie, Goldszmid, Romina S
Format: Article
Language:English
Subjects:
CD8-Positive T-Lymphocytes
Cell Line, Tumor
Colorectal Neoplasms
Humans
Lymphocyte Count
Myeloid Cells - pathology
Tumor Microenvironment
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Description
Summary:Immune checkpoint blockade has dramatically improved cancer therapy but remains ineffective for most colorectal tumors. In this issue of Immunity, Peuker et al. describe a microbiota-myeloid-tumor cell crosstalk that inhibits CD8 T cells and promotes colorectal cancer progression.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2022.03.011