RIP(K)ing away immunotherapy resistance

Interferon signaling mediates resistance to immune checkpoint blockade therapy, but the underlying mechanisms are poorly understood. In this issue of Immunity, Cucolo et al. identify RIPK1 as an interferon-stimulated gene with potent effects on cell extrinsic and intrinsic immunotherapy resistance.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2022-04, Vol.55 (4), p.580-582
Main Authors: Patel, Mira A, Tavazoie, Sohail F
Format: Article
Language:English
Subjects:
Drug Resistance, Neoplasm
Humans
Immunologic Factors
Immunotherapy
Interferons
Neoplasms
Receptor-Interacting Protein Serine-Threonine Kinases
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Description
Summary:Interferon signaling mediates resistance to immune checkpoint blockade therapy, but the underlying mechanisms are poorly understood. In this issue of Immunity, Cucolo et al. identify RIPK1 as an interferon-stimulated gene with potent effects on cell extrinsic and intrinsic immunotherapy resistance.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2022.03.010