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HLA‐identical living related kidney transplantation: Outcomes of a national multicenter study

Objectives The kidney prognosis of HLA‐identical seems theoretically very interesting with the lowest risk of acute rejection after that of identical twins. Objectives were to determine the prevalence of acute rejection and various complications in a cohort of HLA‐identical living‐related kidney tra...

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Published in:International journal of urology 2022-06, Vol.29 (6), p.519-524
Main Authors: Bentata, Yassamine, ElKabbaj, Driss, Bahadi, Abdelaali, Rhou, Hakima, Laouad, Inass, Sqalli, Tarik, Bouattar, Tarik, Ouzeddoun, Naima, Bayahia, Rabia, Ramdani, Benyouns
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container_end_page 524
container_issue 6
container_start_page 519
container_title International journal of urology
container_volume 29
creator Bentata, Yassamine
ElKabbaj, Driss
Bahadi, Abdelaali
Rhou, Hakima
Laouad, Inass
Sqalli, Tarik
Bouattar, Tarik
Ouzeddoun, Naima
Bayahia, Rabia
Ramdani, Benyouns
description Objectives The kidney prognosis of HLA‐identical seems theoretically very interesting with the lowest risk of acute rejection after that of identical twins. Objectives were to determine the prevalence of acute rejection and various complications in a cohort of HLA‐identical living‐related kidney transplant. Methods A retrospective, multicenter study was conducted in seven university centers in Morocco, which included all recipients of an HLA‐identical living‐related kidney transplant performed between 1990 and 2019. Results Data on 68 HLA‐identical living‐related kidney transplants were collected. The donors were siblings in 89.7%, the parents in 7.3%, and identical twins in 3% of cases. 53.6% of all recipients were under 35 years old, and 59.4% of them were male. 39.7% of all donors were under 35 years old, and 47% of them were male. 48.5% of HLA‐identical living‐related kidney transplants were performed before the year 2000. 18 kidney transplant biopsies were performed on 16 kidney transplant recipients. Seven episodes of acute rejection occurred in six patients, 8.8% of the whole cohort (n = 68). Two cases of acute rejection among the seven were related to poor adherence, cessation of immunosuppressive therapy, and loss of medical follow‐up by these patients. These two patients were 20 years old at the time of kidney transplantation. The global kidney transplant survival was 66.7% versus 91.9% (P = 0.04) in the two patient groups having developed acute rejection and not having developed acute rejection, respectively. Conclusions Acute rejection is a real threat to HLA‐identical kidney transplant recipients. Therefore, it seems very important to codify the immunosuppressive regimen and to adopt a minimal and effective treatment.
doi_str_mv 10.1111/iju.14827
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Objectives were to determine the prevalence of acute rejection and various complications in a cohort of HLA‐identical living‐related kidney transplant. Methods A retrospective, multicenter study was conducted in seven university centers in Morocco, which included all recipients of an HLA‐identical living‐related kidney transplant performed between 1990 and 2019. Results Data on 68 HLA‐identical living‐related kidney transplants were collected. The donors were siblings in 89.7%, the parents in 7.3%, and identical twins in 3% of cases. 53.6% of all recipients were under 35 years old, and 59.4% of them were male. 39.7% of all donors were under 35 years old, and 47% of them were male. 48.5% of HLA‐identical living‐related kidney transplants were performed before the year 2000. 18 kidney transplant biopsies were performed on 16 kidney transplant recipients. Seven episodes of acute rejection occurred in six patients, 8.8% of the whole cohort (n = 68). Two cases of acute rejection among the seven were related to poor adherence, cessation of immunosuppressive therapy, and loss of medical follow‐up by these patients. These two patients were 20 years old at the time of kidney transplantation. The global kidney transplant survival was 66.7% versus 91.9% (P = 0.04) in the two patient groups having developed acute rejection and not having developed acute rejection, respectively. Conclusions Acute rejection is a real threat to HLA‐identical kidney transplant recipients. Therefore, it seems very important to codify the immunosuppressive regimen and to adopt a minimal and effective treatment.</description><identifier>ISSN: 0919-8172</identifier><identifier>EISSN: 1442-2042</identifier><identifier>DOI: 10.1111/iju.14827</identifier><identifier>PMID: 35427442</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>acute rejection ; Biopsy ; Donors ; Graft rejection ; Histocompatibility antigen HLA ; HLA‐identical ; Immunosuppressive agents ; Kidney transplantation ; Kidney transplants ; living donor ; Medical prognosis ; Patients ; transplant survival ; Twins</subject><ispartof>International journal of urology, 2022-06, Vol.29 (6), p.519-524</ispartof><rights>2022 The Japanese Urological Association</rights><rights>2022 The Japanese Urological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3377-cfa293fd65c17e156f1492b0acbe9d5c248a7ae4157327231c6ed164747612cc3</cites><orcidid>0000-0002-9404-6995</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35427442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bentata, Yassamine</creatorcontrib><creatorcontrib>ElKabbaj, Driss</creatorcontrib><creatorcontrib>Bahadi, Abdelaali</creatorcontrib><creatorcontrib>Rhou, Hakima</creatorcontrib><creatorcontrib>Laouad, Inass</creatorcontrib><creatorcontrib>Sqalli, Tarik</creatorcontrib><creatorcontrib>Bouattar, Tarik</creatorcontrib><creatorcontrib>Ouzeddoun, Naima</creatorcontrib><creatorcontrib>Bayahia, Rabia</creatorcontrib><creatorcontrib>Ramdani, Benyouns</creatorcontrib><title>HLA‐identical living related kidney transplantation: Outcomes of a national multicenter study</title><title>International journal of urology</title><addtitle>Int J Urol</addtitle><description>Objectives The kidney prognosis of HLA‐identical seems theoretically very interesting with the lowest risk of acute rejection after that of identical twins. Objectives were to determine the prevalence of acute rejection and various complications in a cohort of HLA‐identical living‐related kidney transplant. Methods A retrospective, multicenter study was conducted in seven university centers in Morocco, which included all recipients of an HLA‐identical living‐related kidney transplant performed between 1990 and 2019. Results Data on 68 HLA‐identical living‐related kidney transplants were collected. The donors were siblings in 89.7%, the parents in 7.3%, and identical twins in 3% of cases. 53.6% of all recipients were under 35 years old, and 59.4% of them were male. 39.7% of all donors were under 35 years old, and 47% of them were male. 48.5% of HLA‐identical living‐related kidney transplants were performed before the year 2000. 18 kidney transplant biopsies were performed on 16 kidney transplant recipients. Seven episodes of acute rejection occurred in six patients, 8.8% of the whole cohort (n = 68). Two cases of acute rejection among the seven were related to poor adherence, cessation of immunosuppressive therapy, and loss of medical follow‐up by these patients. These two patients were 20 years old at the time of kidney transplantation. The global kidney transplant survival was 66.7% versus 91.9% (P = 0.04) in the two patient groups having developed acute rejection and not having developed acute rejection, respectively. Conclusions Acute rejection is a real threat to HLA‐identical kidney transplant recipients. Therefore, it seems very important to codify the immunosuppressive regimen and to adopt a minimal and effective treatment.</description><subject>acute rejection</subject><subject>Biopsy</subject><subject>Donors</subject><subject>Graft rejection</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA‐identical</subject><subject>Immunosuppressive agents</subject><subject>Kidney transplantation</subject><subject>Kidney transplants</subject><subject>living donor</subject><subject>Medical prognosis</subject><subject>Patients</subject><subject>transplant survival</subject><subject>Twins</subject><issn>0919-8172</issn><issn>1442-2042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKBDEQRYMoOj4W_oAE3Oiina4knXS7E_HJgBtdh0y6WjL2Y0y6ldn5CX6jX2KcUReCtSkoTh0ul5B9SE8gztjNhhMQOVNrZARCsISlgq2TUVpAkeSg2BbZDmGWpsAZ5Jtki2eCqQiOiL6enH28vbsS295ZU9Pavbj2kXqsTY8lfXJliwvae9OGeW3a3vSua0_p3dDbrsFAu4oa2i6v8bsZ6qiJLvQ09EO52CUblakD7n3vHfJweXF_fp1M7q5uzs8mieVcqcRWhhW8KmVmQSFksgJRsGlq7BSLMrNM5EYZFJApzhTjYCWWIIUSSgKzlu-Qo5V37rvnAUOvGxcs1jEydkPQTGYgc1kAj-jhH3TWDT6m_6KiW2ZFqiJ1vKKs70LwWOm5d43xCw2p_mpdx9b1svXIHnwbh2mD5S_5U3MExivg1dW4-N-kb24fVspPDJKMmA</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Bentata, Yassamine</creator><creator>ElKabbaj, Driss</creator><creator>Bahadi, Abdelaali</creator><creator>Rhou, Hakima</creator><creator>Laouad, Inass</creator><creator>Sqalli, Tarik</creator><creator>Bouattar, Tarik</creator><creator>Ouzeddoun, Naima</creator><creator>Bayahia, Rabia</creator><creator>Ramdani, Benyouns</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9404-6995</orcidid></search><sort><creationdate>202206</creationdate><title>HLA‐identical living related kidney transplantation: Outcomes of a national multicenter study</title><author>Bentata, Yassamine ; ElKabbaj, Driss ; Bahadi, Abdelaali ; Rhou, Hakima ; Laouad, Inass ; Sqalli, Tarik ; Bouattar, Tarik ; Ouzeddoun, Naima ; Bayahia, Rabia ; Ramdani, Benyouns</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3377-cfa293fd65c17e156f1492b0acbe9d5c248a7ae4157327231c6ed164747612cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>acute rejection</topic><topic>Biopsy</topic><topic>Donors</topic><topic>Graft rejection</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA‐identical</topic><topic>Immunosuppressive agents</topic><topic>Kidney transplantation</topic><topic>Kidney transplants</topic><topic>living donor</topic><topic>Medical prognosis</topic><topic>Patients</topic><topic>transplant survival</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bentata, Yassamine</creatorcontrib><creatorcontrib>ElKabbaj, Driss</creatorcontrib><creatorcontrib>Bahadi, Abdelaali</creatorcontrib><creatorcontrib>Rhou, Hakima</creatorcontrib><creatorcontrib>Laouad, Inass</creatorcontrib><creatorcontrib>Sqalli, Tarik</creatorcontrib><creatorcontrib>Bouattar, Tarik</creatorcontrib><creatorcontrib>Ouzeddoun, Naima</creatorcontrib><creatorcontrib>Bayahia, Rabia</creatorcontrib><creatorcontrib>Ramdani, Benyouns</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bentata, Yassamine</au><au>ElKabbaj, Driss</au><au>Bahadi, Abdelaali</au><au>Rhou, Hakima</au><au>Laouad, Inass</au><au>Sqalli, Tarik</au><au>Bouattar, Tarik</au><au>Ouzeddoun, Naima</au><au>Bayahia, Rabia</au><au>Ramdani, Benyouns</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA‐identical living related kidney transplantation: Outcomes of a national multicenter study</atitle><jtitle>International journal of urology</jtitle><addtitle>Int J Urol</addtitle><date>2022-06</date><risdate>2022</risdate><volume>29</volume><issue>6</issue><spage>519</spage><epage>524</epage><pages>519-524</pages><issn>0919-8172</issn><eissn>1442-2042</eissn><abstract>Objectives The kidney prognosis of HLA‐identical seems theoretically very interesting with the lowest risk of acute rejection after that of identical twins. 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ispartof International journal of urology, 2022-06, Vol.29 (6), p.519-524
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subjects acute rejection
Biopsy
Donors
Graft rejection
Histocompatibility antigen HLA
HLA‐identical
Immunosuppressive agents
Kidney transplantation
Kidney transplants
living donor
Medical prognosis
Patients
transplant survival
Twins
title HLA‐identical living related kidney transplantation: Outcomes of a national multicenter study
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