Antioxidant and inflammatory biomarkers in herpes zoster

The risk of herpes zoster (HZ) increases as cell‐mediated immunity declines with age. Even though oxidative stress plays a crucial role in the development of HZ, there are few serum biomarkers of the disease's antioxidant activity. The purpose of this study is to investigate the blood levels of...

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Bibliographic Details
Published in:Journal of medical virology 2022-08, Vol.94 (8), p.3924-3929
Main Authors: Oskay, Tuba, Keskin, Cem, Özen, Mehmet
Format: Article
Language:English
Subjects:
albumin
Albumins
antioxidant status
Antioxidants
Bilirubin
Biomarkers
Blood levels
Calciferol
CRP
Herpes zoster
Herpes Zoster - complications
Herpesvirus 3, Human
Homocysteine
Humans
Inflammation
Neuralgia
Neuralgia, Postherpetic
Oxidative stress
Patients
PHN
Retrospective Studies
Serum levels
Statistical analysis
total bilirubin
Uric acid
Varicella
Virology
Viruses
Vitamin D
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Summary:The risk of herpes zoster (HZ) increases as cell‐mediated immunity declines with age. Even though oxidative stress plays a crucial role in the development of HZ, there are few serum biomarkers of the disease's antioxidant activity. The purpose of this study is to investigate the blood levels of major antioxidants in HZ patients. To the best of our knowledge, this is the first study on this issue in the literature. The serum levels of antioxidants including uric acid (UA), total bilirubin (TBİL), albumin (ALB), vitamin D levels, and inflammatory markers such as homocysteine (Hcy) and C‐reactive protein (CRP) was retrospectively analyzed in 53 patients with HZ and 53 age‐and sex‐matched healthy controls (HCs). The relationships between these markers and postherpetic neuralgia (PHN) and the clinical severity of HZ were also evaluated. Serum levels of UA, TBIL, and ALB in patients with HZ were significantly lower than those in the HCs (p 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27781