Cytokine mass balance levels in donation after circulatory death donors using hemoadsorption: Case series report

The use of hemadsorption has been purposed to reduce cytokine levels during the reperfusion phase during donation after circulatory death (DCD) programs. This paper aims to describe a cases series of the inflammatory cytokine levels before and after hemadsorption during normothermic reperfusion in D...

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Published in:International journal of artificial organs 2022-07, Vol.45 (7), p.642-646
Main Authors: Baroni, Stefano, Marudi, Andrea, Rinaldi, Simone, Ghedini, Silvia, Magistri, Paolo, Piero Guerrini, Gian, Olivieri, Tiziana, Dallai, Chiara, Talamonti, Marta, Maccieri, Jessica, Benedetto, Fabrizio Di, Bertellini, Elisabetta
Format: Article
Language:English
Subjects:
Adsorption
Cytokines
Hemadsorption
Inflammation
Interleukin 10
Kidney diseases
Kidneys
Liver
Liver diseases
Mass balance
Reperfusion
Tumor necrosis factor-α
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cited_by cdi_FETCH-LOGICAL-c368t-4b7b257ca736eda32cefdf2b0f5b717f10dcdaf9f45282f2c624f09ba9baa4dc3
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container_title International journal of artificial organs
container_volume 45
creator Baroni, Stefano
Marudi, Andrea
Rinaldi, Simone
Ghedini, Silvia
Magistri, Paolo
Piero Guerrini, Gian
Olivieri, Tiziana
Dallai, Chiara
Talamonti, Marta
Maccieri, Jessica
Benedetto, Fabrizio Di
Bertellini, Elisabetta
description The use of hemadsorption has been purposed to reduce cytokine levels during the reperfusion phase during donation after circulatory death (DCD) programs. This paper aims to describe a cases series of the inflammatory cytokine levels before and after hemadsorption during normothermic reperfusion in DCD donors of liver and kidneys. In this observational pilot paper, we describe 8 DCD donors of liver or kidneys in our center from the year 2018 to 2019. All DCD donor subjects had similar age, were younger than 60 years, without evident critical conditions, no liver or kidney dysfunction known, and they presented with poor neurological outcomes instrumentally and clinically documented. We observed in our patients an interesting reduction of IL-10 and TNF-α levels during the normothermic reperfusion with hemadsorption. We transplanted all livers and kidneys from DCD donors without significant compliances.
doi_str_mv 10.1177/03913988221091288
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identifier ISSN: 0391-3988
ispartof International journal of artificial organs, 2022-07, Vol.45 (7), p.642-646
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1724-6040
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source SAGE
subjects Adsorption
Cytokines
Hemadsorption
Inflammation
Interleukin 10
Kidney diseases
Kidneys
Liver
Liver diseases
Mass balance
Reperfusion
Tumor necrosis factor-α
title Cytokine mass balance levels in donation after circulatory death donors using hemoadsorption: Case series report
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