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Overweight and obese youth with type 1 or type 2 diabetes share similar elevation in triglycerides during middle and late adolescence
Overweight and obesity have been observed in children with type 1 diabetes (T1D). This further increases their future risk of Cardiovascular Disease (CVD) as well as the development of other risk factors, such as dyslipidemia. To compare lipid profiles in children and adolescents with Type 1 diabete...
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| Published in: | Obesity research & clinical practice 2022-03, Vol.16 (2), p.138-143 |
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| container_title | Obesity research & clinical practice |
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| creator | Ashour, Dina AlSubaihin, Abdulmajeed Lim, Yvonne Yijuan Legault, Laurent |
| description | Overweight and obesity have been observed in children with type 1 diabetes (T1D). This further increases their future risk of Cardiovascular Disease (CVD) as well as the development of other risk factors, such as dyslipidemia.
To compare lipid profiles in children and adolescents with Type 1 diabetes and lean mass (T1L), Type 1 diabetes and overweight or obese (T1OW/OB), and type 2 diabetes (T2D).
This was a cross-sectional study of 669 patients with T1D or T2D aged 2–19 years using retrospective data collected from 2003 to 2014. Included patients were categorized into lean (BMI |
| doi_str_mv | 10.1016/j.orcp.2022.03.003 |
| format | article |
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To compare lipid profiles in children and adolescents with Type 1 diabetes and lean mass (T1L), Type 1 diabetes and overweight or obese (T1OW/OB), and type 2 diabetes (T2D).
This was a cross-sectional study of 669 patients with T1D or T2D aged 2–19 years using retrospective data collected from 2003 to 2014. Included patients were categorized into lean (BMI < 85th ile and overweight or Obese (BMI ≥ 85th ile). Patients were subcategorized into three age groups: < 10 years, 10–14 years, and 15–19 years.
7.6% of patients had T2D. Of the patients with T1D, 58.9% were lean, 26.4% were overweight, and 14.7% were obese. Total Cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C) and Non-HDL-C levels were similar across groups. In the 15–19 years group, Triglycerides (TG) levels were significantly higher in T1OW/OB and similar to T2D. High-density lipoprotein Cholesterol (HDL-C) was significantly lower in T2D. Weight status significantly correlated with TG and HDL-C levels in T1D and T2D groups.
T1OW/OB constitutes a significant proportion of the T1D population. Patients with obesity and T1D, especially if in their late adolescence, have an adverse lipid profile pattern that is comparable to adolescents with T2D. Based on these findings, risk for future CVD in T1OW/OB and T2D may be equivalent.
•A significant proportion of Adolescents with Type 1 diabetes is overweight or obese.•Type 2 diabetes, when compared with Type 1 diabetes and overweight or obesity, is associated with higher triglycerides.•Extent of hypertriglyceridemia was similar in overweight or obese late adolescents with type 1 or type diabetes.•Prevalence of hypercholesterolemia, measured by Non-HDL-C, varries according to weight category in adolescnets with diabetes.</description><identifier>ISSN: 1871-403X</identifier><identifier>EISSN: 1878-0318</identifier><identifier>DOI: 10.1016/j.orcp.2022.03.003</identifier><identifier>PMID: 35430167</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Cardiovascular Diseases - epidemiology ; Child ; Cholesterol ; Cross-Sectional Studies ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Dyslipidemias ; Humans ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Overweight - complications ; Retrospective Studies ; Triglycerides</subject><ispartof>Obesity research & clinical practice, 2022-03, Vol.16 (2), p.138-143</ispartof><rights>2022 The Authors</rights><rights>Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-74d274181cef57f0e83c8c5b397f67bd3ec936d2c90aae268444a9116efbe68b3</citedby><cites>FETCH-LOGICAL-c400t-74d274181cef57f0e83c8c5b397f67bd3ec936d2c90aae268444a9116efbe68b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35430167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashour, Dina</creatorcontrib><creatorcontrib>AlSubaihin, Abdulmajeed</creatorcontrib><creatorcontrib>Lim, Yvonne Yijuan</creatorcontrib><creatorcontrib>Legault, Laurent</creatorcontrib><title>Overweight and obese youth with type 1 or type 2 diabetes share similar elevation in triglycerides during middle and late adolescence</title><title>Obesity research & clinical practice</title><addtitle>Obes Res Clin Pract</addtitle><description>Overweight and obesity have been observed in children with type 1 diabetes (T1D). This further increases their future risk of Cardiovascular Disease (CVD) as well as the development of other risk factors, such as dyslipidemia.
To compare lipid profiles in children and adolescents with Type 1 diabetes and lean mass (T1L), Type 1 diabetes and overweight or obese (T1OW/OB), and type 2 diabetes (T2D).
This was a cross-sectional study of 669 patients with T1D or T2D aged 2–19 years using retrospective data collected from 2003 to 2014. Included patients were categorized into lean (BMI < 85th ile and overweight or Obese (BMI ≥ 85th ile). Patients were subcategorized into three age groups: < 10 years, 10–14 years, and 15–19 years.
7.6% of patients had T2D. Of the patients with T1D, 58.9% were lean, 26.4% were overweight, and 14.7% were obese. Total Cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C) and Non-HDL-C levels were similar across groups. In the 15–19 years group, Triglycerides (TG) levels were significantly higher in T1OW/OB and similar to T2D. High-density lipoprotein Cholesterol (HDL-C) was significantly lower in T2D. Weight status significantly correlated with TG and HDL-C levels in T1D and T2D groups.
T1OW/OB constitutes a significant proportion of the T1D population. Patients with obesity and T1D, especially if in their late adolescence, have an adverse lipid profile pattern that is comparable to adolescents with T2D. Based on these findings, risk for future CVD in T1OW/OB and T2D may be equivalent.
•A significant proportion of Adolescents with Type 1 diabetes is overweight or obese.•Type 2 diabetes, when compared with Type 1 diabetes and overweight or obesity, is associated with higher triglycerides.•Extent of hypertriglyceridemia was similar in overweight or obese late adolescents with type 1 or type diabetes.•Prevalence of hypercholesterolemia, measured by Non-HDL-C, varries according to weight category in adolescnets with diabetes.</description><subject>Adolescent</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Child</subject><subject>Cholesterol</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Dyslipidemias</subject><subject>Humans</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Overweight - complications</subject><subject>Retrospective Studies</subject><subject>Triglycerides</subject><issn>1871-403X</issn><issn>1878-0318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kMtu3CAUhlGVqrm0L9BFxDIbu9xsYymbKErbSJGyaaXuEIbjGUbYTABPNA_Q9y6TSbLsBv7Fd34OH0JfKakpoe23TR2i2daMMFYTXhPCP6AzKjtZEU7lyUumlSD8zyk6T2lDSNP0gn9Cp7wRvDR0Z-jv4w7iM7jVOmM9WxwGSID3Yclr_OzKkfdbwBSHeEwMW6cHyJBwWusIOLnJeR0xeNjp7MKM3YxzdCu_NxCdLaBdoptXeHLWenh5xetcgg0ekoHZwGf0cdQ-wZfX-wL9_n736_Zn9fD44_725qEygpBcdcKyTlBJDYxNNxKQ3EjTDLzvxrYbLAfT89Yy0xOtgbVSCKF7SlsYB2jlwC_Q1bF3G8PTAimryZUNvNczhCUp1jbFppSEFpQdURNDShFGtY1u0nGvKFEH_WqjDvrVQb8iXBX9ZejytX8ZJrDvI2--C3B9BKD8cucgqmTcwYB1EUxWNrj_9f8DxFGYkA</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Ashour, Dina</creator><creator>AlSubaihin, Abdulmajeed</creator><creator>Lim, Yvonne Yijuan</creator><creator>Legault, Laurent</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202203</creationdate><title>Overweight and obese youth with type 1 or type 2 diabetes share similar elevation in triglycerides during middle and late adolescence</title><author>Ashour, Dina ; AlSubaihin, Abdulmajeed ; Lim, Yvonne Yijuan ; Legault, Laurent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-74d274181cef57f0e83c8c5b397f67bd3ec936d2c90aae268444a9116efbe68b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Child</topic><topic>Cholesterol</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Dyslipidemias</topic><topic>Humans</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Overweight - complications</topic><topic>Retrospective Studies</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashour, Dina</creatorcontrib><creatorcontrib>AlSubaihin, Abdulmajeed</creatorcontrib><creatorcontrib>Lim, Yvonne Yijuan</creatorcontrib><creatorcontrib>Legault, Laurent</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity research & clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashour, Dina</au><au>AlSubaihin, Abdulmajeed</au><au>Lim, Yvonne Yijuan</au><au>Legault, Laurent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overweight and obese youth with type 1 or type 2 diabetes share similar elevation in triglycerides during middle and late adolescence</atitle><jtitle>Obesity research & clinical practice</jtitle><addtitle>Obes Res Clin Pract</addtitle><date>2022-03</date><risdate>2022</risdate><volume>16</volume><issue>2</issue><spage>138</spage><epage>143</epage><pages>138-143</pages><issn>1871-403X</issn><eissn>1878-0318</eissn><abstract>Overweight and obesity have been observed in children with type 1 diabetes (T1D). This further increases their future risk of Cardiovascular Disease (CVD) as well as the development of other risk factors, such as dyslipidemia.
To compare lipid profiles in children and adolescents with Type 1 diabetes and lean mass (T1L), Type 1 diabetes and overweight or obese (T1OW/OB), and type 2 diabetes (T2D).
This was a cross-sectional study of 669 patients with T1D or T2D aged 2–19 years using retrospective data collected from 2003 to 2014. Included patients were categorized into lean (BMI < 85th ile and overweight or Obese (BMI ≥ 85th ile). Patients were subcategorized into three age groups: < 10 years, 10–14 years, and 15–19 years.
7.6% of patients had T2D. Of the patients with T1D, 58.9% were lean, 26.4% were overweight, and 14.7% were obese. Total Cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C) and Non-HDL-C levels were similar across groups. In the 15–19 years group, Triglycerides (TG) levels were significantly higher in T1OW/OB and similar to T2D. High-density lipoprotein Cholesterol (HDL-C) was significantly lower in T2D. Weight status significantly correlated with TG and HDL-C levels in T1D and T2D groups.
T1OW/OB constitutes a significant proportion of the T1D population. Patients with obesity and T1D, especially if in their late adolescence, have an adverse lipid profile pattern that is comparable to adolescents with T2D. Based on these findings, risk for future CVD in T1OW/OB and T2D may be equivalent.
•A significant proportion of Adolescents with Type 1 diabetes is overweight or obese.•Type 2 diabetes, when compared with Type 1 diabetes and overweight or obesity, is associated with higher triglycerides.•Extent of hypertriglyceridemia was similar in overweight or obese late adolescents with type 1 or type diabetes.•Prevalence of hypercholesterolemia, measured by Non-HDL-C, varries according to weight category in adolescnets with diabetes.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>35430167</pmid><doi>10.1016/j.orcp.2022.03.003</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity research & clinical practice, 2022-03, Vol.16 (2), p.138-143 |
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| source | ScienceDirect Freedom Collection |
| subjects | Adolescent Cardiovascular Diseases - epidemiology Child Cholesterol Cross-Sectional Studies Diabetes mellitus Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Dyslipidemias Humans Obesity Obesity - complications Obesity - epidemiology Overweight - complications Retrospective Studies Triglycerides |
| title | Overweight and obese youth with type 1 or type 2 diabetes share similar elevation in triglycerides during middle and late adolescence |
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