Association of Bowman’s capsule rupture with prognosis in patients with lupus nephritis

Background and objective Lupus nephritis is one of the most severe manifestations of systemic lupus erythematosus. The clinical and prognostic significance of Bowman’s capsule rupture in patients with lupus nephritis is unknown. Methods One hundred eighty patients with lupus nephritis were enrolled...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nephrology 2022-05, Vol.35 (4), p.1193-1204
Main Authors: Duan, Tongyue, Zhu, Xuejing, Zhao, Qing, Xiao, Li, He, Liyu, Liu, Hong, Chen, Anqun, Duan, Shaobin, Yuan, Shuguang, Tang, Chengyuan, Yuan, Fang, Zhu, Jianling, Zhu, Xiaoping, Cheng, Meichu, Liu, Yinghong, Liu, Yu, Liu, Fuyou, Sun, Lin
Format: Article
Language:English
Subjects:
Bowman Capsule - metabolism
Bowman Capsule - pathology
Creatinine
Female
Humans
Kidney - pathology
Kidney Failure, Chronic - metabolism
Lupus Nephritis - diagnosis
Lupus Nephritis - pathology
Male
Medicine
Medicine & Public Health
Nephrology
original Article
Prognosis
Retrospective Studies
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and objective Lupus nephritis is one of the most severe manifestations of systemic lupus erythematosus. The clinical and prognostic significance of Bowman’s capsule rupture in patients with lupus nephritis is unknown. Methods One hundred eighty patients with lupus nephritis were enrolled in the study and the integrity of Bowman’s capsule was assessed. Both inflammatory and proliferative cells were detected by immunochemistry staining. The primary events of interest were end-stage renal disease and death. Results After retrospective analysis of the data, 52 (28.9%) patients were found to have Bowman’s capsule rupture, which was accompanied by high levels of serum creatinine, 24 h urine protein, and Activity/Chronicity Index. Bowman’s capsule rupture was correlated with the level of crescents, tubular atrophy, and interstitial fibrosis. The number of CD20 + cells was higher in the Bowman’s capsule rupture ( +) group compared with the Bowman’s capsule rupture (−) group, while no differences in other inflammatory cells were observed. In addition, the end stage renal disease-free survival in the Bowman’s capsule rupture ( +) group was lower than in the Bowman’s capsule rupture (−) group. Moreover, serum creatinine (HR 39.56, P  
ISSN:1724-6059
1724-6059
DOI:10.1007/s40620-022-01316-x