Polymeric film containing pomegranate peel extract as a promising tool for the treatment of candidiasis

Polymeric films containing pomegranate peel extract (PPE) can act as a drug-delivery platform for topical treatment of candidiasis. The composition, mechanical resistance, and antifungal activity of a polymeric film containing PPE at 1.25 mg.mL were investigated. Films were prepared using a solvent...

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Bibliographic Details
Published in:Natural product research 2023-02, Vol.37 (4), p.603-607
Main Authors: de Paula, Geanne Aparecida, Costa, Nubya Nascimento, da Silva, Thais Martins, Bastos, Kamila Arêas, Ignacchiti, Mariana Drummond Costa, Severi, Juliana Aparecida, Oréfice, Rodrigo Lambert, Carreira, Lílian Gasparelli, Villanova, Janaina Cecília Oliveira, Resende, Juliana Alves
Format: Article
Language:English
Subjects:
Antifungal activity
Antifungal Agents - pharmacology
Candida albicans
Candidiasis
Candidiasis - drug therapy
Drug delivery
Elongation
Fungicides
Mechanical properties
Plant extracts
Plant Extracts - pharmacology
Polymer films
Polymers
Pomegranate
Stability analysis
Tensile strength
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Summary:Polymeric films containing pomegranate peel extract (PPE) can act as a drug-delivery platform for topical treatment of candidiasis. The composition, mechanical resistance, and antifungal activity of a polymeric film containing PPE at 1.25 mg.mL were investigated. Films were prepared using a solvent casting technique. The incorporation of PPE in the polymeric matrix gave rise to homogeneous, smooth, shiny, and yellowish-brown films. FTIR spectra of the film containing PPE showed differences without compromising the stability of the extract and the matrix. SEM analysis showed the existence of interruptions in the continuity of the films with extract, which promoted a reduction in the mechanical parameters without significantly changing the tensile strength and elongation at break. Films showed adequate mechanical properties and antifungal activity against , , and .
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2064464