Activation of TRPV1 by capsaicin-loaded CaCO3 nanoparticle for tumor-specific therapy

Capsaicin is a natural non-toxic small molecular organic substance, which is often used clinically to reduce inflammation and pain. Here, we report an acid-responsive CaCO3 nanoparticle loaded with capsaicin that can specifically activate TRPV1 channels and trigger tumor calcium ion therapy. The exc...

Full description

Saved in:
Bibliographic Details
Published in:Biomaterials 2022-05, Vol.284, p.121520-121520, Article 121520
Main Authors: Xu, Mengqing, Zhang, Jin, Mu, Yongli, Foda, Mohamed Frahat, Han, Heyou
Format: Article
Language:English
Subjects:
Acidity-responsive
Ca2+ influx
CaCO3 nanoparticles
Natural capsaicin
TRPV1 activation
Tumor therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Capsaicin is a natural non-toxic small molecular organic substance, which is often used clinically to reduce inflammation and pain. Here, we report an acid-responsive CaCO3 nanoparticle loaded with capsaicin that can specifically activate TRPV1 channels and trigger tumor calcium ion therapy. The excellent acid responsiveness of calcium carbonate enables it to precisely target the tumor sites. The released capsaicin can specifically activate TRPV1 channel, overloading the intracellular calcium ion concentration and causing cell apoptosis, which provides a new safer and cheaper treatment. We proved that the naturalness and non-toxicity of capsaicin make the CaCO3@CAP nanoparticles have excellent biocompatibility, which has good development prospects and clinical application potential.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2022.121520