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Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4’-dimethylaminochalcone
Mercury (Hg) is an element with high toxicity, especially to the nervous system, and fluorescent pigments are used to visualize dynamic processes in living cells. A little explored fluorescent core is chalcone. Herein, we synthesized chalcone ( 2E )-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-on...
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Published in: | Journal of fluorescence 2022-07, Vol.32 (4), p.1449-1456 |
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creator | Mellado, Marco Roldán, Nicole Miranda, Rodrigo Aguilar, Luis F. Bravo, Manuel A. Quiroz, Waldo |
description | Mercury (Hg) is an element with high toxicity, especially to the nervous system, and fluorescent pigments are used to visualize dynamic processes in living cells. A little explored fluorescent core is chalcone. Herein, we synthesized chalcone (
2E
)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one (
8
) and assessed its photophysical properties. Moreover, the application of this chemosensor in aqueous media shows a selective fluorescence quenching effect with Hg(II). The figures of merit for the chemosensor were calculated to be LOD = 136 nM and LOQ = 454 nM, as well as a stoichiometry of 1:1. Furthermore, the association constant (K
a
) and fluorescence quenching constant (K
SV
) were calculated using the Benesi–Hildebrand and Stern–Volmer equations to be K
a
= 9.08 × 10
4
and K
SV
= 1.60 × 10
5
, respectively. Finally, by using a computational approach, we explain the interaction between chalcone (
8
) and Hg(II) and propose a potential quenching mechanism based on the blocking of photoinduced electron transfer. |
doi_str_mv | 10.1007/s10895-022-02941-2 |
format | article |
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2E
)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one (
8
) and assessed its photophysical properties. Moreover, the application of this chemosensor in aqueous media shows a selective fluorescence quenching effect with Hg(II). The figures of merit for the chemosensor were calculated to be LOD = 136 nM and LOQ = 454 nM, as well as a stoichiometry of 1:1. Furthermore, the association constant (K
a
) and fluorescence quenching constant (K
SV
) were calculated using the Benesi–Hildebrand and Stern–Volmer equations to be K
a
= 9.08 × 10
4
and K
SV
= 1.60 × 10
5
, respectively. Finally, by using a computational approach, we explain the interaction between chalcone (
8
) and Hg(II) and propose a potential quenching mechanism based on the blocking of photoinduced electron transfer.</description><identifier>ISSN: 1053-0509</identifier><identifier>EISSN: 1573-4994</identifier><identifier>DOI: 10.1007/s10895-022-02941-2</identifier><identifier>PMID: 35441925</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analytical Chemistry ; Aqueous solutions ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedicine ; Biophysics ; Biotechnology ; Chemical sensors ; Chemoreceptors ; Electron transfer ; Fluorescence ; Mathematical analysis ; Mercury (metal) ; Mercury compounds ; Nervous system ; Original Article ; Pigments ; Quenching ; Stoichiometry ; Toxicity</subject><ispartof>Journal of fluorescence, 2022-07, Vol.32 (4), p.1449-1456</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-70a8eb63a1808898694fa43aaaee91407fe5eb5954686979492f46fde2b93ca73</citedby><cites>FETCH-LOGICAL-c305t-70a8eb63a1808898694fa43aaaee91407fe5eb5954686979492f46fde2b93ca73</cites><orcidid>0000-0003-4727-1089 ; 0000-0001-9577-5180</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35441925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mellado, Marco</creatorcontrib><creatorcontrib>Roldán, Nicole</creatorcontrib><creatorcontrib>Miranda, Rodrigo</creatorcontrib><creatorcontrib>Aguilar, Luis F.</creatorcontrib><creatorcontrib>Bravo, Manuel A.</creatorcontrib><creatorcontrib>Quiroz, Waldo</creatorcontrib><title>Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4’-dimethylaminochalcone</title><title>Journal of fluorescence</title><addtitle>J Fluoresc</addtitle><addtitle>J Fluoresc</addtitle><description>Mercury (Hg) is an element with high toxicity, especially to the nervous system, and fluorescent pigments are used to visualize dynamic processes in living cells. A little explored fluorescent core is chalcone. Herein, we synthesized chalcone (
2E
)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one (
8
) and assessed its photophysical properties. Moreover, the application of this chemosensor in aqueous media shows a selective fluorescence quenching effect with Hg(II). The figures of merit for the chemosensor were calculated to be LOD = 136 nM and LOQ = 454 nM, as well as a stoichiometry of 1:1. Furthermore, the association constant (K
a
) and fluorescence quenching constant (K
SV
) were calculated using the Benesi–Hildebrand and Stern–Volmer equations to be K
a
= 9.08 × 10
4
and K
SV
= 1.60 × 10
5
, respectively. Finally, by using a computational approach, we explain the interaction between chalcone (
8
) and Hg(II) and propose a potential quenching mechanism based on the blocking of photoinduced electron transfer.</description><subject>Analytical Chemistry</subject><subject>Aqueous solutions</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Chemical sensors</subject><subject>Chemoreceptors</subject><subject>Electron transfer</subject><subject>Fluorescence</subject><subject>Mathematical analysis</subject><subject>Mercury (metal)</subject><subject>Mercury compounds</subject><subject>Nervous system</subject><subject>Original Article</subject><subject>Pigments</subject><subject>Quenching</subject><subject>Stoichiometry</subject><subject>Toxicity</subject><issn>1053-0509</issn><issn>1573-4994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc1KLDEQhYMo6lVfwIU0uNFFa-WvO1mK-DMguFDXIdNTPRPpTjTpFtz5Gr7efRIzd7wKLlwUCZyvTlVyCNmncEIB6tNEQWlZAmO5tKAlWyPbVNa8FFqL9XwHyUuQoLfIn5QeAUAroTbJFpdCUM3kNrF36JMb3AsWbTeGiKlBPxTNAvuQshRi0ea6nh9NJseF84V9HjGMqUihGwcXfDEm5-eF-Pv2Xs5cj8PitbO986FZ2K4JHnfJRmu7hHuf5w55uLy4P78ub26vJudnN2XDQQ5lDVbhtOKWKlBKq0qL1gpurUXUVEDdosSp1FJUWau10KwVVTtDNtW8sTXfIUcr36cY8o5pML3Lj-k665cLG1ZJpipOKc3o4Q_0MYzR5-0yld2BM72k2IpqYkgpYmueouttfDUUzDIAswrA5ADMvwAMy00Hn9bjtMfZV8v_H88AXwEpS36O8Xv2L7Yf0u-RnQ</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Mellado, Marco</creator><creator>Roldán, Nicole</creator><creator>Miranda, Rodrigo</creator><creator>Aguilar, Luis F.</creator><creator>Bravo, Manuel A.</creator><creator>Quiroz, Waldo</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4727-1089</orcidid><orcidid>https://orcid.org/0000-0001-9577-5180</orcidid></search><sort><creationdate>20220701</creationdate><title>Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4’-dimethylaminochalcone</title><author>Mellado, Marco ; Roldán, Nicole ; Miranda, Rodrigo ; Aguilar, Luis F. ; Bravo, Manuel A. ; Quiroz, Waldo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-70a8eb63a1808898694fa43aaaee91407fe5eb5954686979492f46fde2b93ca73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analytical Chemistry</topic><topic>Aqueous solutions</topic><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biophysics</topic><topic>Biotechnology</topic><topic>Chemical sensors</topic><topic>Chemoreceptors</topic><topic>Electron transfer</topic><topic>Fluorescence</topic><topic>Mathematical analysis</topic><topic>Mercury (metal)</topic><topic>Mercury compounds</topic><topic>Nervous system</topic><topic>Original Article</topic><topic>Pigments</topic><topic>Quenching</topic><topic>Stoichiometry</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mellado, Marco</creatorcontrib><creatorcontrib>Roldán, Nicole</creatorcontrib><creatorcontrib>Miranda, Rodrigo</creatorcontrib><creatorcontrib>Aguilar, Luis F.</creatorcontrib><creatorcontrib>Bravo, Manuel A.</creatorcontrib><creatorcontrib>Quiroz, Waldo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of fluorescence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mellado, Marco</au><au>Roldán, Nicole</au><au>Miranda, Rodrigo</au><au>Aguilar, Luis F.</au><au>Bravo, Manuel A.</au><au>Quiroz, Waldo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4’-dimethylaminochalcone</atitle><jtitle>Journal of fluorescence</jtitle><stitle>J Fluoresc</stitle><addtitle>J Fluoresc</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>32</volume><issue>4</issue><spage>1449</spage><epage>1456</epage><pages>1449-1456</pages><issn>1053-0509</issn><eissn>1573-4994</eissn><abstract>Mercury (Hg) is an element with high toxicity, especially to the nervous system, and fluorescent pigments are used to visualize dynamic processes in living cells. A little explored fluorescent core is chalcone. Herein, we synthesized chalcone (
2E
)-3-(4-(dimethylamino)phenyl)-1-phenylprop-2-en-1-one (
8
) and assessed its photophysical properties. Moreover, the application of this chemosensor in aqueous media shows a selective fluorescence quenching effect with Hg(II). The figures of merit for the chemosensor were calculated to be LOD = 136 nM and LOQ = 454 nM, as well as a stoichiometry of 1:1. Furthermore, the association constant (K
a
) and fluorescence quenching constant (K
SV
) were calculated using the Benesi–Hildebrand and Stern–Volmer equations to be K
a
= 9.08 × 10
4
and K
SV
= 1.60 × 10
5
, respectively. Finally, by using a computational approach, we explain the interaction between chalcone (
8
) and Hg(II) and propose a potential quenching mechanism based on the blocking of photoinduced electron transfer.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35441925</pmid><doi>10.1007/s10895-022-02941-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4727-1089</orcidid><orcidid>https://orcid.org/0000-0001-9577-5180</orcidid></addata></record> |
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subjects | Analytical Chemistry Aqueous solutions Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedicine Biophysics Biotechnology Chemical sensors Chemoreceptors Electron transfer Fluorescence Mathematical analysis Mercury (metal) Mercury compounds Nervous system Original Article Pigments Quenching Stoichiometry Toxicity |
title | Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4’-dimethylaminochalcone |
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