Vulvovaginal candidiasis: An overview of mycological, clinical, and immunological aspects

Aim To provide an overview of clinical, immunological, and mycological aspects of vulvovaginal candidiasis (VVC). Methods A literature search was conducted to find relevant articles about different aspects of VVC. Related data from retrieved articles were summarized in different headings. Results VV...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2022-07, Vol.48 (7), p.1546-1560
Main Authors: Jafarzadeh, Leila, Ranjbar, Maryam, Nazari, Tina, Naeimi Eshkaleti, Mahsa, Aghaei Gharehbolagh, Sanaz, Sobel, Jack D., Mahmoudi, Shahram
Format: Article
Language:English
Subjects:
antifungal agents
Candida
Candidiasis
Diabetes mellitus
Drug resistance
herbal medicine
natural products
Patients
Post-menopause
vulvovaginal candidiasis
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Summary:Aim To provide an overview of clinical, immunological, and mycological aspects of vulvovaginal candidiasis (VVC). Methods A literature search was conducted to find relevant articles about different aspects of VVC. Related data from retrieved articles were summarized in different headings. Results VVC has a global distribution and Candida albicans is the leading cause of infection except for specific patient groups like postmenopausal, diabetic, or immunocompromised women. VVC has a range of clinical presentations, accordingly, its diagnosis should be based on clinical examination coupled with laboratory investigations. The best therapeutic regimen depends on the patient's conditions and the causative agent. Moreover, factors like drug resistance of the causative agents and different mutations in the immunity‐related genes could affect the treatment outcome. Conclusion As a globally distributed disease, VVC needs further attention, especially in areas related to the treatment failure and recurrence of the disease.
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.15267