Effects of almond on cardiometabolic outcomes in patients with type 2 diabetes: A systematic review and meta‐analysis of randomized controlled trials

An enhanced risk for cardiovascular disease (CVD) still exists even when T2DM patients have tight control on blood sugar. Thus, identification of treatment approaches that address CVD risk factors may be useful for patients beyond the blood sugar management. Although emerging evidence suggests that...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2022-05, Vol.36 (5), p.1839-1853
Main Authors: Moosavian, Seyedeh Parisa, Rahimlou, Mehran, Rezaei Kelishadi, Mahnaz, Moradi, Sajjad, Jalili, Cyrus
Format: Article
Language:English
Subjects:
almond
Blood pressure
Body fat
Body mass
Body mass index
Body size
cardiometabolic
Cardiovascular diseases
Cholesterol
Clinical trials
Density
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Health risks
Heart diseases
Hemoglobin
Heterogeneity
Insulin
Low density lipoprotein
Meta-analysis
Nuts
Patients
Risk analysis
Risk factors
Risk management
Search engines
Sensitivity analysis
Subgroups
Systematic review
Triglycerides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An enhanced risk for cardiovascular disease (CVD) still exists even when T2DM patients have tight control on blood sugar. Thus, identification of treatment approaches that address CVD risk factors may be useful for patients beyond the blood sugar management. Although emerging evidence suggests that nuts consumption have beneficial effects on cardiometabolic health, the effects of almond intake in patients with type 2 diabetes are still controversial. Therefore, our objective was to investigate the effect of almond on cardiometabolic outcomes in patients with T2DM through a systematic review and meta‐analysis of available randomized controlled trials (RCTs). A systematic search was conducted in PubMed, Web of Science, Scopus, Embase, and Google Scholar to identify relevant RCTs up to March 2021. There was no language and time limitation. Weighted mean difference (WMD) was pooled using a random effects model. Heterogeneity, sensitivity analysis, and publication bias were reported using standard methods. Nine RCTs were included in the final analysis. Almond intake resulted in significant reduction in low‐density lipoprotein cholesterol (LDL‐C) (WMD: −5.28 mg/dL; 95% CI, −9.92, −0.64; p = .026) compared with the control group. This lowering effect of LDL‐C was robust in subgroups with almond consumption >50 g/day, and baseline LDL‐C level
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7365