Risk factors for asthma in patients with allergic rhinitis in eastern China

• Published in: American journal of otolaryngology 2022-05, Vol.43 (3), p.103426-103426, Article 103426
• Main Authors: Zhao, Li, Yang, Yan, Zang, Yi Ran, Zhang, Qin Qin, Liang, Xu, Yuan, Guang Mei, Jin, Peng, Zi, Xiao Xue, Yu, Ke Na, Zhang, Hai Ling, Shi, Li
• Format: Article
• Language: English
• Subjects: Age; Allergens; Allergens - adverse effects; Allergic rhinitis; Allergies; Animals; Asthma; Asthma - epidemiology; China - epidemiology; Chronic illnesses; Comorbidity; Cross-Sectional Studies; Dander; Dermatophagoides farinae; Dogs; Emergency medical care; Family medical history; Hospitals; Humans; Hypersensitivity; Patients; Pyroglyphidae; Regression analysis; Rhinitis; Rhinitis, Allergic - epidemiology; Risk analysis; Risk factor; Risk Factors; Skin tests; Skin-prick tests
• ISSN: 0196-0709; 1532-818X
• DOI: 10.1016/j.amjoto.2022.103426

Asthma is one of the most common chronic diseases among children and adults and can lead to a high health and socioeconomic burden. Allergic rhinitis (AR) often precedes the development of asthma. This study aims to clarify the risk factors for cocurrent asthma in patients with AR in eastern China. A cross-sectional study of 3739 patients with AR was performed in eastern China. Patients meeting the criteria for AR were evaluated using a skin-prick test (SPT) of 16 common aeroallergens. A logistic regression analysis was used to assess the risk factors of asthma in patients with AR. The prevalence of asthma in patients with AR was 14.23%. The patients sensitive to dust mites (D. farinae and D. pteronyssinus) had the highest prevalence (76.84% and 73.68%). A significant difference was found in sensitization to four types of allergens (D. farinae, D. pteronyssinus, dog dander, Alternaria alternata) in patients with AR with and without asthma. The strongest risk factor for asthma in patients with AR was an allergy to Aspergillus fumigatus (adjusted OR, 2.42; 95% CI, 1.50–3.90), followed by allergy to D. pteronyssinus (adjusted OR, 2.06; 1.30–3.27), and allergy to dog dander (adjusted OR, 1.92; 1.24–2.97). Various risk factors that are independently associated with asthma in patients with AR were found in different age groups. We observed a difference in risk factors in patients with AR with and without asthma. Clarifying the risk factors for asthma in patients with AR is important and may be beneficial to the optimal interventions of asthma.