Release of metal elements from the Essure implant: A prospective cohort study

•Significant levels of Ni, Cr and Sn in the fallopian tube from symptomatic patients with Essure®.•Differential concentrations of metal elements in the peritoneal fluid.•Differential levels of metal elements according to the length of time between Essure® placement and removal. The causal mechanisti...

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Published in:European journal of obstetrics & gynecology and reproductive biology 2022-06, Vol.273, p.20-25
Main Authors: Parant, François, Bost, Muriel, Nohuz, Erdogan, Prost, Julie, Cerruto, Emanuele, Moret, Stephanie, Maurin, Julien, Chene, Gautier
Format: Article
Language:English
Subjects:
Chromium
Essure® removal
Female
Humans
Laparoscopy - adverse effects
Metal trace elements
Metals - adverse effects
Nickel
Prospective Studies
Sterilization, Tubal - adverse effects
Tin
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Summary:•Significant levels of Ni, Cr and Sn in the fallopian tube from symptomatic patients with Essure®.•Differential concentrations of metal elements in the peritoneal fluid.•Differential levels of metal elements according to the length of time between Essure® placement and removal. The causal mechanistic relationships between Essure® and adverse effects are unclear, but corrosion in the in-vivo environment with release of metal ions may be suspected. Here we evaluated the concentrations of nickel (Ni), chromium (Cr) and tin (Sn) in the peritoneal fluid (PF) and in the fallopian tube (FT) during laparoscopic Essure® removal compared to a control group. Ni, Cr and Sn concentrations were determined in the PF and FT from two groups(group A: symptomatic patients with Essure®) vs group B (control group without Essure®) by Inductively Coupled Plasma Mass Spectrometry analysis. Correlation between metal elements concentrations and reported pre-operative symptoms was also investigated. There were 131 patients in group A vs 92 control patients in group B. The concentrations of Cr and Ni in PF between both groups were significantly different (p 
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2022.04.014