Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets

Growing evidences show a direct link between diarrhea and disorders of gut microbiota in pigs. However, whether there are microbial markers associated with post-weaning diarrhea remains unknown. In the current study, we compared the microbial community, functions and metabolites between healthy wean...

Full description

Saved in:
Bibliographic Details
Published in:Science China. Life sciences 2022-10, Vol.65 (10), p.2062-2075
Main Authors: Ren, Wen, Yu, Bing, Yu, Jie, Zheng, Ping, Huang, Zhiqing, Luo, Junqiu, Mao, Xiangbing, He, Jun, Yan, Hui, Wu, Jinlong, Chen, Daiwen, Luo, Yuheng
Format: Article
Language:English
Subjects:
Abundance
Amino acids
Bacteroides
Biomedical and Life Sciences
Carbohydrate metabolism
Carbohydrates
Diarrhea
Fecal microflora
Feces
Hogs
Intestinal microflora
Life Sciences
Lipid metabolism
Metabolism
Metabolites
Metabolomics
Metagenomics
Microbiota
Research Paper
Weaning
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Growing evidences show a direct link between diarrhea and disorders of gut microbiota in pigs. However, whether there are microbial markers associated with post-weaning diarrhea remains unknown. In the current study, we compared the microbial community, functions and metabolites between healthy weaned piglets (group H, n =7) and piglets with post-weaning diarrhea (group D, n =7), in order to find out diarrhea associated microbial markers. Each of 7 fecal samples was collected from H and D piglets (weaned at 21 d and sampled at 26 d). The metagenomic and untargeted metabolomic analysis revealed that the microbial composition, function and metabolic profile in D pigs was considerably reshaped, including the reduced abundance and number of Bacteroides , which significantly correlated with the diarrhea status of host. The carbohydrate metabolism, biosynthesis and metabolism, lipid metabolism, amino acid metabolism, and the activity of glycan and carbohydrates digestion related enzymes showed extensively down-regulated in D pigs compared with H pigs. Diarrhea significantly changed the metabolic profiles of fecal microbiota, and most of the altered metabolites were negatively or positively correlated with the change in the abundance of Bacteroides. In conclusion, the lower abundance of Bacteroides and its associated metabolic dysfunction may be regarded as microbial markers of physiological post-weaning diarrhea in piglets.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-021-2068-6