Limosilactobacillus fermentum, Current Evidence on the Antioxidant Properties and Opportunities to be Exploited as a Probiotic Microorganism

The unbalance in the production and removal of oxygen-reactive species in the human organism leads to oxidative stress, a physiological condition commonly linked to the occurrence of cancer, neurodegenerative, inflammatory, and metabolic disorders. The implications of oxidative stress in the gut hav...

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Bibliographic Details
Published in:Probiotics and antimicrobial proteins 2022-10, Vol.14 (5), p.960-979
Main Authors: Paulino do Nascimento, Luciana Caroline, Lacerda, Diego Cabral, Ferreira, Diorginis José Soares, de Souza, Evandro Leite, de Brito Alves, José Luiz
Format: Article
Language:English
Subjects:
Antioxidants
Applied Microbiology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Clinical trials
Disease control
Dysbacteriosis
Intestinal microflora
Limosilactobacillus fermentum
Metabolic disorders
Microbiology
Microbiota
Nutrition
Oxidants
Oxidative stress
Phenotypes
Probiotics
Protein Science
Strains (organisms)
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Summary:The unbalance in the production and removal of oxygen-reactive species in the human organism leads to oxidative stress, a physiological condition commonly linked to the occurrence of cancer, neurodegenerative, inflammatory, and metabolic disorders. The implications of oxidative stress in the gut have been associated with gut microbiota impairments and gut dysbiosis. Some lactobacilli strains have shown an efficient antioxidant system capable of protecting against oxidative stress and related-chronic diseases. Recently, in vitro and experimental studies and some clinical trials have demonstrated the efficacy of the administration of various Limosilactobacillus fermentum strains to modulate beneficially the host antioxidant system resulting in the amelioration of a variety of systemic diseases phenotypes. This review presents and discusses the currently available studies on identifying L. fermentum strains with anti-oxidant properties, their sources, range of the administered doses, and duration of the intervention in experiments with animals and clinical trials. This review strives to serve as a relevant and well-cataloged reference of L. fermentum strains with capabilities of inducing anti-oxidant effects and health-promoting benefits to the host, envisaging their broad applicability to disease control.
ISSN:1867-1306
1867-1314
DOI:10.1007/s12602-022-09943-3