Dermoscopic furrow ink test of the palmar lesion in loricrin keratoderma

Palmoplantar keratodermas (PPK) comprise a heterogeneous group of keratinization disorders that gradually progress during childhood, resulting in difficulties to establish a diagnosis and to identify a candidate gene for sequencing. Dermoscopic examination with staining of palmoplantar skin using a...

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Bibliographic Details
Published in:Journal of dermatology 2022-08, Vol.49 (8), p.783-786
Main Authors: Shirahama, Toshihiro, Hamada, Takahiro, Abe, Toshifumi, Arakawa, Masataka, Teye, Kwesi, Koga, Hiroshi, Ishii, Norito, Nakama, Takekuni
Format: Article
Language:English
Subjects:
Case reports
Children
Dermatology
dermoscopic furrow ink test
genodermatoses
Hands
ichthyosis
Keratinization
Lesions
loricrin keratoderma
Microscopy
palmoplantar keratoderma
Physical characteristics
Sweat gland
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Summary:Palmoplantar keratodermas (PPK) comprise a heterogeneous group of keratinization disorders that gradually progress during childhood, resulting in difficulties to establish a diagnosis and to identify a candidate gene for sequencing. Dermoscopic examination with staining of palmoplantar skin using a whiteboard marker, so‐called “furrow ink test”, could be a useful tool for differentiation between furrow and ridge in understanding the morphological characteristics of PPK. One of the striking features in autosomal dominant loricrin keratoderma (LK) is diffuse PPK with honeycomb pattern. In this study, we performed dermoscopic furrow ink test in a Japanese family of LK with the most frequent mutation c.684dup, p.Ser229Valfs*107 in the loricrin gene. The severe lesion revealed that irregular circular hyperkeratoses were aggregated and normal structures of furrows and ridges were disrupted. To accurately describe the nature of this dermoscopic patterned skin surface, we suggest that the condition could be termed as “irregular cobblestone appearance” rather than “honeycomb pattern”. Regular cobblestone appearance to maintain parallel furrow structure was observed in early or mild hyperkeratotic lesions. Eccrine sweat glands that open on the surface of ridges nearly disappeared, resulting in hypohidrosis.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.16405