Cryobiopsy and dye marking guided by electromagnetic navigation bronchoscopy before resection of pulmonary nodule

Our aims were to explore the feasibility, safety, and efficacy of peroperative transbronchial lung cryobiopsy (TBLC) guided by electromagnetic navigation bronchoscopy (ENB) and ENB-guided methylene blue marking of presumably non-palpable pulmonary nodules, and to assess its impact on video-assisted...

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Bibliographic Details
Published in:Respiratory medicine and research 2022-05, Vol.81, p.100911-100911, Article 100911
Main Authors: Taton, Olivier, Sokolow, Youri, Bondue, Benjamin, Vandermeeren, Chloé, Kuylen, Maarten Vander, Gevenois, Pierre Alain, Remmelink, Myriam, Mekinda Ngono, Zita, Berghmans, Thierry, Leduc, Dimitri
Format: Article
Language:English
Subjects:
Cryobiopsy
Dye marking
Electromagnetic navigation bronchoscopy
Small pulmonary nodule
Video-assisted thoracoscopy
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Summary:Our aims were to explore the feasibility, safety, and efficacy of peroperative transbronchial lung cryobiopsy (TBLC) guided by electromagnetic navigation bronchoscopy (ENB) and ENB-guided methylene blue marking of presumably non-palpable pulmonary nodules, and to assess its impact on video-assisted thoracoscopic surgery (VATS) and postoperative lung function. This approach was applied to 16 consecutive patients (Group A, mean age 64 years) who were compared retrospectively to a historical group of 49 patients (Group B, mean age 62 years) with similar nodules resected without guidance. The usefulness of dye marking was graded. The success rates of both ENB-guided TBLC and nodule localization through dye marking were computed. The type of resection, volume of resected parenchyma, duration of procedures, and postoperative lung function were compared between groups. Unpaired t-test, chi-square test, unpaired Wilcoxon test, and exact Fisher test were used when appropriate. Malignancy was pathologically proven in all patients. TBLC revealed malignancy in 9 patients in Group A. The success rate of ENB-guided dye marking was 94%. Lobectomy was less frequently performed in Group A than in Group B (p = 0.022). Forced expiratory volume in 1 s and total lung capacity were significantly less reduced in Group A than in Group B (p = 0.006 and p = 0.019, respectively). Combined procedure was longer than surgery alone (p
ISSN:2590-0412
2590-0412
DOI:10.1016/j.resmer.2022.100911