Cardiac Rehabilitation Improves Endothelial Function in Coronary Artery Disease Patients

Abstract Exercise-based cardiac rehabilitation may be an effective non-pharmacological intervention for improving endothelial function in coronary artery disease patients. Therefore, this systematic review with meta-analysis aimed to (a) estimate the training-induced effect on endothelial and vascul...

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Bibliographic Details
Published in:International journal of sports medicine 2022-10, Vol.43 (11), p.905-920
Main Authors: Manresa-Rocamora, Agustín, Ribeiro, Fernando, Casanova-Lizón, Antonio, Flatt, Andrew A., Sarabia, José Manuel, Moya-Ramón, Manuel
Format: Article
Language:English
Subjects:
Cardiovascular disease
Confidence intervals
Coronary vessels
Muscle function
Rehabilitation
Review
Smooth muscle
Vein & artery diseases
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Summary:Abstract Exercise-based cardiac rehabilitation may be an effective non-pharmacological intervention for improving endothelial function in coronary artery disease patients. Therefore, this systematic review with meta-analysis aimed to (a) estimate the training-induced effect on endothelial and vascular smooth muscle function, assessed by flow-mediated dilation and nitroglycerin-mediated dilation, respectively, in coronary artery disease patients; and to (b) study the influence of potential trial-level variables (i. e. study and intervention characteristics) on the training-induced effect on endothelial and vascular smooth muscle function. Electronic searches were performed in Pubmed, Scopus, and Embase up to February 2021. Random-effects models of standardised mean change were estimated. Heterogeneity analyses were performed by using the Chi 2 test and I 2 index. Our results showed that exercise-based cardiac rehabilitation significantly enhanced flow-mediated dilation (1.04 [95% confidence interval=0.76 to 1.31]) but did not significantly change nitroglycerin-mediated dilation (0.05 [95% confidence interval=–0.03 to 0.13]). Heterogeneity testing reached statistical significance ( p< .001) with high inconsistency for flow-mediated dilation ( I 2 = 92%). Nevertheless, none of the analysed variables influenced the training-induced effect on flow-mediated dilation. Exercise-based cardiac rehabilitation seems to be an effective therapeutic strategy for improving endothelial-dependent dilation in coronary artery disease patients, which may aid in the prevention of cardiovascular events.
ISSN:0172-4622
1439-3964
DOI:10.1055/a-1717-1798