Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagy

Mitostasis, the process of mitochondrial maintenance by biogenesis and degradative mechanisms, is challenged by the extreme length of axons. PINK1 (PTEN induced putative kinase 1) is a mitochondrial protein that targets damaged mitochondria for mitophagy. In reconciling the short half-life of PINK1...

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Bibliographic Details
Published in:Autophagy 2022-12, Vol.18 (12), p.3048-3049
Main Authors: Harbauer, Angelika B., Schwarz, Thomas L.
Format: Article
Language:English
Subjects:
Autophagic Punctum
Autophagy - physiology
Axonal biology
Axons - metabolism
local translation
mitochondria
Mitochondria - metabolism
Mitochondrial Proteins - metabolism
mitophagy
Mitophagy - genetics
Protein Kinases - genetics
Protein Kinases - metabolism
RNA transport
RNA, Messenger - genetics
RNA, Messenger - metabolism
Ubiquitin-Protein Ligases - metabolism
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Summary:Mitostasis, the process of mitochondrial maintenance by biogenesis and degradative mechanisms, is challenged by the extreme length of axons. PINK1 (PTEN induced putative kinase 1) is a mitochondrial protein that targets damaged mitochondria for mitophagy. In reconciling the short half-life of PINK1 with the need for mitophagy of damaged axonal mitochondria, we found that axonal mitophagy depends on local translation of the Pink1 mRNA. Using live-cell imaging, we detected co-transport of the Pink1 mRNA on mitochondria in neurons, which is crucial for mitophagy in distal parts of the cell. Here we discuss how the coupling of the transcript of a short-lived mitochondrial protein to the movement of its target organelles contributes to our understanding of mitostasis in neurons.
ISSN:1554-8627
1554-8635
DOI:10.1080/15548627.2022.2070332