Reproductive complications after stroke: Long-lasting impairment of gonadotropin-releasing hormone neuronal network?

Some studies have demonstrated that stroke may increase the risk of pregnancy complications and early menopause. In addition, preclinical investigations revealed the middle cerebral artery occlusion could affect hypothalamus. Since hypothalamus is the core of central circuits regulating reproductive...

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Bibliographic Details
Published in:Biology of reproduction 2022-08, Vol.107 (2), p.368-370
Main Authors: Salehi, Mohammad Saied, Pandamooz, Sareh, Tamadon, Amin, Jafarzadeh Shirazi, Mohammad Reza, Borhani-Haghighi, Afshin
Format: Article
Language:English
Subjects:
Cerebral blood flow
cerebral ischemia
early menopause
FORUM
glutamate excitotoxicity
GnRH
Gonadotropin-releasing hormone
Gonadotropins
HPA axis
Hypothalamus
Ischemia
Menopause
Pituitary (anterior)
Pregnancy
pregnancy complication
Pregnancy complications
Stroke
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Summary:Some studies have demonstrated that stroke may increase the risk of pregnancy complications and early menopause. In addition, preclinical investigations revealed the middle cerebral artery occlusion could affect hypothalamus. Since hypothalamus is the core of central circuits regulating reproductive processes, impairment of hypothalamic gonadotropin-releasing hormone neuronal network following stroke might be manifested in long-lasting reproductive disorders. Graphical Abstract
ISSN:0006-3363
1529-7268
DOI:10.1093/biolre/ioac080